Monitoring patients with juvenile idiopathic arthritis using health-related quality of life
| Autor: | Nathan Buijsse, Joost F. Swart, Nico M Wulffraat, Mark Klein, Sytze de Roock, Vicki L. Seyfert-Margolis, Martijn J. H. Doeleman, Gouke J. Bonsel |
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| Přispěvatelé: | Public Health |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Adolescent Health-related quality of life Population Arthritis Monitoring Ambulatory EQ-5D-Y-5 L 03 medical and health sciences Juvenile Arthritis Disease Activity Score Diagnostic Self Evaluation 0302 clinical medicine Mobile applications Rheumatology Quality of life Internal medicine Immunology and Allergy Medicine Juvenile Humans 030212 general & internal medicine Disease activity education Child Juvenile idiopathic arthritis Health-related quality of life EQ-5D-Y-5 L Disease activity Remote monitoring Mobile applications E-health Retrospective Studies 030203 arthritis & rheumatology Health related quality of life education.field_of_study E-health Receiver operating characteristic business.industry lcsh:RJ1-570 lcsh:Pediatrics Juvenile idiopathic arthritis medicine.disease Arthritis Juvenile Remote monitoring Pediatrics Perinatology and Child Health Quality of Life Female lcsh:RC925-935 business Research Article |
| Zdroj: | Pediatric Rheumatology, 19, 1. BMC Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-7 (2021) Pediatric Rheumatology Online Journal Pediatric Rheumatology, 19(1):40. BioMed Central Ltd. |
| ISSN: | 1546-0096 |
| Popis: | Background Pediatric patients with juvenile idiopathic arthritis (JIA) are at risk for a lower health-related quality of life compared to their healthy peers. Remote monitoring of health-related quality of life using electronic patient-reported outcomes could provide important information to treating physicians. The aim of this study was to investigate if self-assessment with the EuroQol five-dimensional ‘youth’ questionnaire with five levels (EQ-5D-Y-5 L) inside a mobile E-health application could identify JIA patients in need of possible treatment adjustments. Methods The EQ-5D-Y-5 L was completed via a mobile application (Reuma2Go) between October 2017 and January 2019. The clinical juvenile arthritis disease activity score with 71 joint count (cJADAS-71) was reported at every corresponding visit as reference for disease activity. Previously described cJADAS-71 thresholds were used to identify patients in possible need of treatment adjustments. Discriminatory power of the EQ-5D-Y-5 L was assessed by ROC-curves and diagnostic characteristics. Results Sixty-eight JIA patients completed the EQ-5D-Y-5 L questionnaire. Median cJADAS-71 indicated low disease activity overall in the studied population. ROC curves and diagnostic characteristics demonstrated that self-assessment with the EQ-5D-Y-5 L could distinguish between patients with inactive disease (or minimal disease activity) and moderate to high disease activity with good accuracy (87%), sensitivity (85%), specificity (89%) and negative predictive value (86%). Conclusions Results demonstrate that the EQ-5D-Y-5 L was able to identify JIA patients in need of possible treatment adjustments in our studied population. Remote monitoring of health-related quality of life and patient-reported outcomes via E-health applications could provide important additional information to determine the frequency of clinical visits, assess therapeutic efficacy and guide treat-to-target strategies in pediatric patients with JIA. |
| Databáze: | OpenAIRE |
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