Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
| Autor: | Benjamin M. Neale, Stephen Sanders, Julian Maller, Thomas Werge, Beate St Pourcain, Jakob Grove, Preben Bo Mortensen, Stephan Ripke, David M. Evans, George Davey Smith, Verneri Anttila, Kaitlin E. Samocha, David Skuse, David M. Hougaard, Elise B. Robinson, Mark J. Daly, Anders D. Børglum, Joanna Martin, Jack A. Kosmicki, Brendan Bulik-Sullivan, Mads V. Hollegaard, Angelica Ronald |
|---|---|
| Přispěvatelé: | i Psych- S. S. I. Broad Autism Group |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Population Population genetics Genome-wide association study Population based Biology behavioral disciplines and activities Article Adaptive functioning psyc Correlation 03 medical and health sciences 0302 clinical medicine mental disorders Genetic variation Genetics medicine Genetic risk education 030304 developmental biology 0303 health sciences education.field_of_study food and beverages medicine.disease 3. Good health Variation (linguistics) Neuropsychiatric disorder 030104 developmental biology Autism spectrum disorder Etiology Autism 030217 neurology & neurosurgery Neuropsychiatric disease Clinical psychology |
| Zdroj: | Nature Genetics Nature genetics Publons Robinson, E B, St Pourcain, B, Anttila, V, Kosmicki, J A, Bulik-Sullivan, B, Grove, J, Maller, J, Samocha, K E, Sanders, S J, Ripke, S, Martin, J, Hollegaard, M V, Werge, T, Hougaard, D M, Neale, B M, Evans, D M, Skuse, D, Mortensen, P B, Børglum, A D, Ronald, A, Smith, G D, Daly, M J, iPSYCH-SSI-Broad Autism Group & Als, T D 2016, ' Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population ', Nature Genetics, vol. 48, pp. 552–555 . https://doi.org/10.1038/ng.3529 |
| ISSN: | 1546-1718 1061-4036 |
| DOI: | 10.1038/ng.3529 |
| Popis: | Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink