Further observations of stopping venom immunotherapy: comparison of patients stopped because of a fall in serum venom-specific IgE to insignificant levels with patients stopped prematurely by self-choice
| Autor: | Renee Lantner, Robert E. Reisman |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Allergy Adolescent medicine.medical_treatment Immunology Venom Immunoglobulin E Radioallergosorbent Test Immunopathology Internal medicine medicine Immunology and Allergy Humans Anaphylaxis Desensitization (medicine) medicine.diagnostic_test biology business.industry Venoms Radioallergosorbent test Insect Bites and Stings medicine.disease eye diseases Surgery Sting Desensitization Immunologic biology.protein Patient Compliance Female business Follow-Up Studies |
| Zdroj: | The Journal of allergy and clinical immunology. 83(6) |
| ISSN: | 0091-6749 |
| Popis: | This study extends our experience applying the criterion of a fall in serum venom-specific IgE (RAST) to insignificant levels as an indication to stop venom immunotherapy (VIT) and compares the follow-up results with the results of re-stings in patients who stopped VIT "prematurely" by self-choice. All patients in both groups had a history of venom anaphylaxis, most with cardiovascular and/or respiratory symptoms and initial elevated serum venom-specific IgE; all patients received VIT. The groups were closely matched for age, sex, nature of initial sting reaction, and insect identification. In the group with low-level RAST titers, the duration of VIT was 6 months to 5 years (mean 2 1/2 years). Re-stings occurred from 1 month to 7 years (mean 2.2 years) after cessation of therapy. There were 75 re-stings in 41 patients with four systemic reactions (10% per patient and 5% per sting). All four reacting patients had tolerated several stings during cessation of VIT before the re-sting systemic reaction; two patients had subsequent stings with no reaction. In the group of patients who stopped VIT for other reasons, the duration of VIT was 5 months to 4 years (mean 1.8 years). Re-stings occurred from 4 months to 6 years (mean 2.1 years) after stopping therapy. There were 74 re-stings in 38 patients with seven systemic reactions in four patients (9.5% per patient and 10.5% per sting). Two of the reacting patients had tolerated stings before the re-sting reaction.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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