The Determination of Poldine Methyl Methosulphate in Biological Fluids
Autor: | J. D. Lewis, K. R. L. Mansford, P. F. Langley, D. Smith |
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Rok vydání: | 1963 |
Předmět: | |
Zdroj: | Journal of Pharmacy and Pharmacology. 15:100-106 |
ISSN: | 2042-7158 0022-3573 |
DOI: | 10.1111/j.2042-7158.1963.tb12753.x |
Popis: | A spectrophotometric method is described for the quantitative determination of the quaternary ammonium compound, poldine methyl methosulphate in aqueous solution and in biological fluids. The method involves coupling with methyl orange with simultaneous extraction into a mixture of ethylene dichloride and isopentanol and the determination of the optical density of the resulting acidified solution. The effect of pH on the coupling and extraction and the specificity of the reaction towards related compounds are examined. |
Databáze: | OpenAIRE |
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