Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
| Autor: | Ic Talbot, Toshiki Mimura, Ulf Helwig, Massimo Campieri, Michael A. Kamm, Gilberto Poggioli, Paolo Gionchetti, Rj Nicholls, Fernando Rizzello, Stefan Schreiber |
|---|---|
| Přispěvatelé: | MIMURA T, RIZZELLO F, HELWIG U, POGGIOLI G, SCHREIBER S, TALBOT IC, NICHOLLS RJ, GIONCHETTI P, CAMPIERI M., KAMM MA. |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Placebo-controlled study Pouchitis Placebo Inflammatory bowel disease Severity of Illness Index law.invention Feces Randomized controlled trial Quality of life law Ciprofloxacin Recurrence Internal medicine Metronidazole Severity of illness medicine Humans business.industry Probiotics Inflammatory Bowel Disease Remission Induction Gastroenterology Middle Aged medicine.disease Ulcerative colitis Surgery Patient Satisfaction Quality of Life Drug Therapy Combination Female business |
| Popis: | Ten to 15% of patients with pouchitis experience refractory or recurrent disease. The aim of this study was to evaluate the effectiveness of a single daily high dose probiotic preparation (VSL#3) in maintaining antibiotic induced remission, and quality of life (QOL), for one year in such patients.Patients with pouchitis at least twice in the previous year or requiring continuous antibiotics, associated with a pouchitis disease activity index (PDAI)or =7 (0 = perfect; 18 = worst), in whom remission was induced by four weeks of combined metronidazole and ciprofloxacin, were randomised to receive VSL#3 6 g or placebo once daily for one year or until relapse. Symptomatic, endoscopic, and histological evaluations were made before, and two and 12 months after randomisation or at the time of relapse. Remission was defined as a clinical PDAIor =2 and endoscopic PDAIor =1. Relapse was defined as an increased clinical PDAI scoreor =2 and increased endoscopic PDAI scoreor =3. QOL was assessed using the inflammatory bowel disease questionnaire (IBDQ).Thirty six patients were randomised: 20 to VSL#3 and 16 to placebo. Remission was maintained at one year in 17 patients (85%) on VSL#3 and in one patient (6%) on placebo (p0.0001). The IBDQ score remained high in the VSL#3 group (p = 0.3) but deteriorated in the placebo group (p = 0.0005).The once daily high dose probiotic VSL#3 is effective in maintaining antibiotic introduced remission for at least a year in patients with recurrent or refractory pouchitis. This is associated with a high level of quality of life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|