Antenatal antioxidant prevents adult hypertension, vascular dysfunction, and microvascular rarefaction associated with in utero exposure to a low-protein diet
| Autor: | Daniel Abran, Nathalie Germain, Catherine Yzydorczyk, Patrick Pladys, Anne Monique Nuyt, Isabelle Lahaie, Jean-Claude Lavoie, Gilles Cambonie, Thierry Ntimbane, Ngoc Loan Oanh Le, Cindy Gauthier, Blandine Comte |
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| Přispěvatelé: | Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada, CHU Sainte-Justine, University of Montreal, Université de Montreal, Département de Nutrition |
| Rok vydání: | 2007 |
| Předmět: |
Aging
medicine.medical_specialty hypertension developmental origin of adult disease Physiology medicine.medical_treatment Vasodilation 030204 cardiovascular system & hematology Biology Microcirculation Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Low-protein diet Pregnancy Physiology (medical) Internal medicine Diet Protein-Restricted medicine Animals oxidative stress Vascular Diseases 030304 developmental biology 0303 health sciences vascular dysfunction Angiotensin II Rats 3. Good health antioxidants Endocrinology Animals Newborn chemistry In utero Prenatal Exposure Delayed Effects Blood Vessels Microvascular Rarefaction Female medicine.symptom [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Vasoconstriction |
| Zdroj: | AJP-Regulatory, Integrative and Comparative Physiology AJP-Regulatory, Integrative and Comparative Physiology, American Physiological Society, 2007, 292 (3), pp.R1236-R1245. ⟨10.1152/ajpregu.00227.2006⟩ |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00227.2006 |
| Popis: | Developmental programming of hypertension is associated with vascular dysfunction characterized by impaired vasodilatation to nitric oxide, exaggerated vasoconstriction to ANG II, and microvascular rarefaction appearing in the neonatal period. Hypertensive adults have indices of increased oxidative stress, and newborns that were nutrient depleted during fetal life have decreased antioxidant defenses and increased susceptibility to oxidant injury. To test the hypothesis that oxidative stress participates in early life programming of hypertension, vascular dysfunction, and microvascular rarefaction associated with maternal protein deprivation, pregnant rats were fed a normal, low protein (LP), or LP plus lazaroid (lipid peroxidation inhibitor) isocaloric diet from the day of conception until delivery. Lazaroid administered along with the LP diet prevented blood pressure elevation, enhanced vasomotor response to ANG II, impaired vasodilatation to sodium nitroprusside, and microvascular rarefaction in adult offspring. Liver total glutathione was significantly decreased in LP fetuses, and kidney eight-isoprostaglandin F2α (8-isoPGF2α) levels were significantly increased in adult LP offspring; these modifications were prevented by lazaroid. Renal nitrotyrosine abundance and blood levels of 1,4-dihydroxynonene and 4-hydroxynonenal-protein adducts were not modified by antenatal diet exposure. This study shows in adult offspring of LP-fed dams prevention of hypertension, vascular dysfunction, microvascular rarefaction, and of an increase in indices of oxidative stress by the administration of lazaroid during gestation. Lazaroid also prevented the decrease in antioxidant glutathione levels in fetuses, suggesting an antenatal mild oxidative stress in offspring of LP-fed dams. These studies support the concept that perinatal oxidative insult can lead to permanent alterations in the cardiovascular system development. |
| Databáze: | OpenAIRE |
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