Human soluble receptor for advanced glycation end products and tumor necrosis factor-α as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes
| Autor: | Avani R. Pradeep, Sandeep Singhal, Vibhuti Garg, Dharmendra Kanoriya |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Receptor for Advanced Glycation End Products Dentistry Inflammation Type 2 diabetes Gastroenterology 03 medical and health sciences 0302 clinical medicine Glycation Internal medicine Diabetes mellitus medicine Humans Periodontitis General Dentistry Tumor Necrosis Factor-alpha business.industry Type 2 Diabetes Mellitus Gingival Crevicular Fluid 030206 dentistry Periodontium Middle Aged medicine.disease Chronic periodontitis Cross-Sectional Studies 030104 developmental biology Diabetes Mellitus Type 2 Chronic Disease Female medicine.symptom business Biomarkers |
| Zdroj: | Journal of Oral Science. 58:547-553 |
| ISSN: | 1880-4926 1343-4934 |
| Popis: | The present study aimed to evaluate the levels of soluble receptor for advanced glycation end products (sRAGE) and tumor necrosis factor-α (TNF-α) in serum and gingival crevicular fluid (GCF) in chronic periodontitis (CP) patients with and without type 2 diabetes mellitus (T2DM). A total of 70 subjects were divided into four groups: group 1 (n = 15; subjects with healthy periodontium); group 2 (n = 20; CP patients); group 3 (n = 20; CP patients with T2DM); and group 4 (n = 15; CP patients without T2DM). The serum and GCF levels of human sRAGE and TNF-α were assessed using enzyme-linked immunosorbent assay and correlated with clinical parameters, including probing depth, gingival index and clinical attachment level. Both sRAGE and TNF-α levels varied with the inflammatory state of the patient; the highest levels of sRAGE were seen in group 1, whereas the lowest levels in group 3 (P < 0.05). Conversely, TNF-α levels were found to be the highest in group 3 and lowest in group 1 (P < 0.05). Thus, human sRAGE and TNF-α can be considered as possible GCF and serum markers of inflammatory activity in CP and T2DM.(J Oral Sci 58, 547-553, 2016). |
| Databáze: | OpenAIRE |
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