Predictive value of serum galectin-3 levels in patients with acute heart failure with preserved ejection fraction
Autor: | Mariano Aguayo-Canela, Luis Galisteo-Almeda, Prado Salamanca-Bautista, María Inmaculada Páez-Rubio, José Luis Arias-Jiménez, José Luis Morales-Rull, Francisco Javier Carrasco-Sánchez, Óscar Aramburu-Bodas, Juan Ignacio Pérez-Calvo |
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Rok vydání: | 2013 |
Předmět: |
Male
medicine.medical_specialty Galectin 3 Galectins Renal function Kaplan-Meier Estimate Internal medicine Clinical endpoint medicine Humans Prospective Studies Aged Aged 80 and over Heart Failure Ejection fraction Proportional hazards model business.industry Hazard ratio Stroke Volume Blood Proteins Brain natriuretic peptide medicine.disease Heart failure Acute Disease Cardiology Female Cardiology and Cardiovascular Medicine Heart failure with preserved ejection fraction business Biomarkers Follow-Up Studies |
Zdroj: | International journal of cardiology. 169(3) |
ISSN: | 1874-1754 |
Popis: | This study was conducted to determine whether galectin-3 (Gal3), a β-galactoside-binding lectin, has usefulness to predict outcomes in patients with heart failure (HF) and preserved left ventricular ejection fraction (LVEF).We measured Gal3, urea, creatinine and natriuretic peptides on admission in 419 selected patients with HF and LVEF over 45%. The primary endpoint was all-cause mortality and/or readmission at one-year follow-up. Multivariable Cox proportional hazards models were generated for Gal3 and classical risk factors. We also evaluated the reclassification of patients on the basis of the different score category after adding Gal3 levels. A total of 219 patients had combined adverse events, and 129 patients died during the follow-up. Kaplan-Meir survival curve showed significantly increased primary endpoint and all-cause mortality according to quartiles of Gal3 (log rank, P0.001). Serum Gal3 levels above median (13.8 ng/ml) was a significant predictor of primary endpoint risk after adjustment for age, estimated glomerular filtration rate, anemia, diabetes, serum sodium, brain natriuretic peptide levels, NYHA class and urea, respectively (hazard ratio 1.43, 95% CI 1.07-1.91 P=0.015). The reclassification index increased significantly after addition of Gal3 (9.5%, P0.001) and the integrated discrimination index was 0.022, (P=0.001). The clinical prediction model with Gal3 increased the c-statistic from 0.711 to 0.731 (difference of 0.020, P=0.001).Serum Gal3 is a strong and independent predictor of unfavorable outcomes in patients with HF and preserved LVEF. We also demonstrated the improvement of adding the new biomarker to the model. |
Databáze: | OpenAIRE |
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