L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management
| Autor: | Fatemeh Saghafi, Javad Hashemi, Sina Negintaji, Razieh Avan, Adeleh Sahebnasagh, Solomon Habtemariam, Mahila Monajati |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Biochemistry law.invention Sepsis Immune system law Carnitine Intensive care Drug Discovery medicine Humans Apelin receptor chemistry.chemical_classification Septic shock business.industry Fatty Acids Organic Chemistry Fatty acid medicine.disease Shock Septic Intensive care unit chemistry Molecular Medicine business medicine.drug |
| Zdroj: | Current Medicinal Chemistry. 29:3300-3323 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867328666211117092345 |
| Popis: | In this review, we discussed the biological targets of carnitine, its effects on immune function, and how L-carnitine supplementation may help critically ill patients. L-carnitine is a potent antioxidant. L-carnitine depletion has been observed in prolonged intensive care unit (ICU) stays, while L-carnitine supplementation has beneficial effects in health promotion and regulation of immunity. It is essential for the uptake of fatty acids into mitochondria. By inhibiting the ubiquitin-proteasome system, down-regulating the apelin receptor in cardiac tissue, and reducing β-oxidation of fatty acid, carnitine may decrease vasopressor requirement in septic shock and improve clinical outcomes of this group of patients. We also reviewed animal and clinical studies that have been recruited for evaluating the beneficial effects of L-carnitine in the management of sepsis/ septic shock. Additional clinical data are required to evaluate the optimal daily dose and duration of L-carnitine supplementation. |
| Databáze: | OpenAIRE |
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