Developmental exposure to polychlorinated biphenyls reduces amphetamine behavioral sensitization in Long–Evans rats
Autor: | Lai Har Chi, Paul J. Kostyniak, Helen J.K. Sable, Susan L. Schantz, Supida Monaikul, Emily Poon |
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Rok vydání: | 2013 |
Předmět: |
Male
Litter (animal) medicine.medical_specialty Dextroamphetamine Time Factors Adult male Administration Oral Motor Activity Toxicology Behavioral sensitization Article Cellular and Molecular Neuroscience Long evans rats Developmental Neuroscience Pregnancy Dopamine Internal medicine medicine Animals Rats Long-Evans Amphetamine Sensitization Central Nervous System Sensitization Dose-Response Relationship Drug Perinatal Exposure Polychlorinated Biphenyls Rats Endocrinology medicine.anatomical_structure Anesthesia Female Psychology medicine.drug |
Zdroj: | Neurotoxicology and Teratology. 38:6-12 |
ISSN: | 0892-0362 |
Popis: | PCBs have long been known to affect dopamine (DA) function in the brain. The current study used an amphetamine behavioral sensitization paradigm in rats developmentally exposed to PCBs. Long–Evans rats were given perinatal exposure to 0, 3, or 6 mg/kg/day PCBs and behavioral sensitization to d -amphetamine (AMPH) was assessed in one adult male and female/litter. Non-exposed (control) males showed increasing locomotor activity to repeated injections of 0.5 mg/kg AMPH, typical of behavioral sensitization. PCB-exposed males showed greater activation to the initial acute AMPH injection, but sensitization occurred later and was blunted relative to controls. Sensitization in control females took longer to develop than in the males, but no exposure-related differences were observed. Analysis of whole brain and serum AMPH content following a final IP injection of 0.5 mg/kg revealed no differences among the exposure groups. Overall, these results indicated developmental PCB exposure can alter the motor-stimulating effects of repeated AMPH injections. Males developmentally exposed to PCBs appeared to be pre-sensitized to AMPH, but quickly showed behavioral tolerance to the same drug dose. Results also revealed the behavioral effect was not due to exposure-induced alterations in AMPH metabolism following PCB exposure. |
Databáze: | OpenAIRE |
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