Interaction of long-chain n-alcohols with fluid DOPC bilayers: a neutron diffraction study
| Autor: | Pavol Balgavy, Viktor I. Petrenko, Daniela Uhríková, Anatoly I Beskrovnyy, Mária Klacsová |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Membrane Fluidity
Physiology Lipid Bilayers Neutron diffraction Biophysics 010402 general chemistry 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Molar ratio Scattering Small Angle Lamellar structure 030304 developmental biology Heavy water 0303 health sciences Chemistry Bilayer N alcohols General Medicine 0104 chemical sciences Neutron Diffraction Crystallography Chain length Alcohols Phosphatidylcholines Long chain |
| Zdroj: | General Physiology and Biophysics. 29:355-361 |
| ISSN: | 0231-5882 |
| DOI: | 10.4149/gpb_2010_04_355 |
| Popis: | Lamellar phases composed of fluid dioleoylphosphatidylcholine (DOPC) bilayers containing alkan-1-ols (CnOH, n = 8, 10, 14, 16, 18 is the number of carbon atoms) at CnOH : DOPC = 0.3 molar ratio and hydrated with heavy water at 20.2 ≥ D2O : DOPC ≥ 14.4 molar ratio were studied by neutron diffraction. The bilayer thickness d(L) and the bilayer surface area A(L) per DOPC at the bilayer-water interface were obtained from the lamellar repeat period d using molecular volumes of DOPC, CnOH and D2O, and the Luzatti's method. Both the d(L) and A(L) increase with the CnOH chain length n at CnOH : DOPC = 0.3 molar ratio: d(L) = (3.888 ± 0.066) + (0.016 ± 0.005)·n (in nm), A(L) = (0.6711 ± 0.0107) + (0.0012 ± 0.0008)·n (in nm²). |
| Databáze: | OpenAIRE |
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