Towards a systematic use of effect biomarkers in population and occupational biomonitoring
| Autor: | Nancy B. Hopf, Hans Verhagen, Emilio Benfenati, Radu Corneliu Duca, Christoph van Thriel, Imran Ali, Peter A. Behnisch, Jos Bessems, Gabriele Leng, Mariana F. Fernández, Alicia Paini, Vicente Mustieles, Anna Bal Price, Francesco Cubadda, Henriqueta Louro, Lorraine Brennan, Arthur David, Maryam Zare Jeddi, Sophie Ndaw, Susana Viegas, Robert Pasanen-Kase |
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| Přispěvatelé: | Universita degli Studi di Padova, Université de Lausanne (UNIL), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), European Commission - Joint Research Centre [Ispra] (JRC), Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (IFADO), Technische Universität Dortmund [Dortmund] (TU), Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Institut national de recherche et de sécurité (Paris) (INRS (Paris)), Flemish Institute for Technological Research (VITO), BioDetection Systems, Laboratoire National de Santé [Luxembourg] (LNS), Istituto Superiore di Sanita [Rome], University College Dublin [Dublin] (UCD), Karolinska Institutet [Stockholm], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Laboratoire d'étude et de recherche en environnement et santé (LERES), University of Granada [Granada], CIBER de Epidemiología y Salud Pública (CIBERESP), Secrétariat d'Etat à l'économie (SECO), Health Canada, Università degli Studi di Padova = University of Padua (Unipd), Université de Lausanne = University of Lausanne (UNIL), Istituto Superiore di Sanità (ISS), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Département Santé Environnement Travail et Génie Sanitaire (DSETGS), Universidad de Granada = University of Granada (UGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
ADVERSE OUTCOME PATHWAYS
010504 meteorology & atmospheric sciences Computer science [SDV]Life Sciences [q-bio] 010501 environmental sciences LYMPHOCYTES 01 natural sciences Occupational safety and health Adverse outcome pathways (AOP) Biomonitoring Adverse Outcome Pathway PLACENTA OXIDATIVE STRESS lcsh:Environmental sciences ASSOCIATIONS General Environmental Science Risk assessment RISK lcsh:GE1-350 education.field_of_study Occupational exposure Hazard 3. Good health Europe Mixture assessment Risk analysis (engineering) Physiologically based pharmacokinetic Human Biomonitoring Life Sciences & Biomedicine Biological Monitoring Environmental Monitoring Adverse Outcome Pathways (AOP) Population Environmental Genotoxicity Environmental Sciences & Ecology Humans EXPOSURE Effect Biomarkers education POLYMORPHISMS BLOOD LEAD 0105 earth and related environmental sciences Exposure assessment Science & Technology Occupational health Mechanism (biology) Physiologically based pharmacokinetic (PBPK) Adverse outcome pathway (AOP) IN-VITRO Environmental Exposure Exposure science 13. Climate action Genotoxicidade Ambiental Environmental Sciences Biomarkers |
| Zdroj: | Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Environment International Environment International, Elsevier, 2021, 146, pp.106257. ⟨10.1016/j.envint.2020.106257⟩ Environment International, Vol 146, Iss, Pp 106257-(2021) Digibug. Repositorio Institucional de la Universidad de Granada instname Environment International, 2021, 146, pp.106257. ⟨10.1016/j.envint.2020.106257⟩ Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 0160-4120 |
| DOI: | 10.1016/j.envint.2020.106257⟩ |
| Popis: | Review Effect biomarkers can be used to elucidate relationships between exposure to environmental chemicals and their mixtures with associated health outcomes, but they are often underused, as underlying biological mechanisms are not understood. We aim to provide an overview of available effect biomarkers for monitoring chemical exposures in the general and occupational populations, and highlight their potential in monitoring humans exposed to chemical mixtures. We also discuss the role of the adverse outcome pathway (AOP) framework and physiologically based kinetic and dynamic (PBK/D) modelling to strengthen the understanding of the biological mechanism of effect biomarkers, and in particular for use in regulatory risk assessments. An interdisciplinary network of experts from the European chapter of the International Society for Exposure Science (ISES Europe) and the Organization for Economic Co-operation and Development (OECD) Occupational Biomonitoring activity of Working Parties of Hazard and Exposure Assessment group worked together to map the conventional framework of biomarkers and provided recommendations for their systematic use. We summarized the key aspects of this work here, and discussed these in three parts. Part I, we inventory available effect biomarkers and promising new biomarkers for the general population based on the H2020 Human Biomonitoring for Europe (HBM4EU) initiative. Part II, we provide an overview AOP and PBK/D modelling use that improved the selection and interpretation of effect biomarkers. Part III, we describe the collected expertise from the OECD Occupational Biomonitoring subtask effect biomarkers in prioritizing relevant mode of actions (MoAs) and suitable effect biomarkers. Furthermore, we propose a tiered risk assessment approach for occupational biomonitoring. Several effect biomarkers, especially for use in occupational settings, are validated. They offer a direct assessment of the overall health risks associated with exposure to chemicals, chemical mixtures and their transformation products. Promising novel effect biomarkers are emerging for biomonitoring of the general population. Efforts are being dedicated to prioritizing molecular and biochemical effect biomarkers that can provide a causal link in exposure-health outcome associations. This mechanistic approach has great potential in improving human health risk assessment. New techniques such as in silico methods (e.g. QSAR, PBK/D modelling) as well as 'omics data will aid this process. Our multidisciplinary review represents a starting point for enhancing the identification of effect biomarkers and their mechanistic pathways following the AOP framework. This may help in prioritizing the effect biomarker implementation as well as defining threshold limits for chemical mixtures in a more structured way. Several ex vivo biomarkers have been proposed to evaluate combined effects including genotoxicity and xeno-estrogenicity. There is a regulatory need to derive effect-based trigger values using the increasing mechanistic knowledge coming from the AOP framework to address adverse health effects due to exposure to chemical mixtures. Such a mechanistic strategy would reduce the fragmentation observed in different regulations. It could also stimulate a harmonized use of effect biomarkers in a more comparable way, in particular for risk assessments to chemical mixtures. Highlights: Reliable effect biomarkers are available for most of the relevant MoAs; Increasing AOP knowledge fosters the use of effect biomarkers in regulatory context; PBK/D models allow interpretation and simulation of biomarkers of effect; An inter-regulatory setting of effect-based trigger values is demanded; Effect-biomarkers have in many cases reached a level of maturity ensuring use in mixture assessments. We would like to thank Dr, Michel Hauser from Swiss SECO, for providing the health based occupational background and Thomas Goen ¨ from German DFG and HBM Commission, Dave Marsh, Exxon Mobile UK (representing CEFIC) and Devika Poddalgoda from Health Canada for their discussions and suggestions in the OECD occupational biomonitoring subtask on effect biomarker. Moreover, we would like to thank Tiina Santonen from Finnish Institute for Occupational Health (FIOH). In addition, we specifically acknowledge the work package 14 (HBM4EU WP14) for their valuable work on the effect biomarkers. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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