The accumulation of malonyldialdehyde, an end product of membrane lipid peroxidation, can cause potassium leak in normal and sickle red blood cells
| Autor: | John Duett, Gary J. Levy, Rufus L. Little, Jean D. Ross, Sushil K. Jain |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Leak Cell Membrane Permeability Thiobarbituric acid Endocrinology Diabetes and Metabolism Potassium chemistry.chemical_element Erythrocytes Abnormal Anemia Sickle Cell Biochemistry Lipid peroxidation Andrology chemistry.chemical_compound Membrane Lipids hemic and lymphatic diseases Malondialdehyde medicine Humans skin and connective tissue diseases Ion transporter Erythrocyte Membrane Osmolar Concentration hemic and immune systems Biological activity Hydrogen-Ion Concentration Middle Aged In vitro Malonates Red blood cell medicine.anatomical_structure chemistry Lipid Peroxidation circulatory and respiratory physiology |
| Zdroj: | Biochemical medicine and metabolic biology. 42(1) |
| ISSN: | 0885-4505 |
| Popis: | This study has examined the effect of malonyldialdehyde (MDA), an end product of lipid peroxidation, on the K+ leak in normal (AA) and sickle (SS) red blood cells (RBCs). In vitro MDA accumulation in human RBCs was accomplished by treating them with exogenous standard MDA. MDA accumulation assessed by the thiobarbituric acid reactivity of in vitro MDA-treated RBCs was comparable to the RBCs in hemolytic anemias. There was a significant K+ leak in AA RBCs after in vitro treatment with MDA. The effect of MDA on the K+ leak was greater in SS RBCs. The increase in cellular K+ leak was significantly positively correlated with the extent of MDA accumulation as assessed by thiobarbituric acid reactivity. |
| Databáze: | OpenAIRE |
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