Mecillinam and ampicillin separately or combined in gram-negative septicemia
| Autor: | I. Juhlin, K. Ganrot-Norlin, K. E. Thulin, G. Kahlmeter, G. Tunevall, M. Jonsson, E. Ekwall, A. Scheja, A. Thorén, S. Cronberg |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Penicillanic Acid Microbial Sensitivity Tests Gastroenterology Enterobacteriaceae Sepsis Internal medicine Ampicillin polycyclic compounds medicine Humans In patient Mecillinam Exanthem Aged business.industry digestive oral and skin physiology Enterobacteriaceae Infections Amdinocillin General Medicine Exanthema Middle Aged biochemical phenomena metabolism and nutrition medicine.disease Surgery Kinetics Infectious Diseases Mic values Combined therapy Drug Therapy Combination Female Gram negative septicemia business Half-Life medicine.drug Every Six Hours |
| Zdroj: | Infection. 8:37-40 |
| ISSN: | 1439-0973 0300-8126 |
| DOI: | 10.1007/bf01677397 |
| Popis: | Of 20 patients with gram-negative septicemia treated with mecillinam alone or in combination with ampicillin, successful therapeutic results were obtained in 16. In 11 patients treated with ampicillin alone, three failures responded successfully to a combination of mecillinam and ampicillin. Mecillinam MIC values of isolated Enterobacteriaceae were 0.05-0.4 micrograms/ml. In patients receiving 5 mg/kg mecillinam intravenously every six hours, the mean 0.5 hour concentration was 11.0 micrograms/ml and in those given 10 mg/kg 23.3 migcrograms/ml. No serious side effects were recorded. One patient on mecillinam developed an exanthema, as did three patients on combined therapy. |
| Databáze: | OpenAIRE |
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