Burst-like conditioning electrical stimulation is more efficacious than continuous stimulation for inducing secondary hyperalgesia in humans
| Autor: | E. N. van den Broeke, S. Gousset, André Mouraux |
|---|---|
| Přispěvatelé: | UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Nociception Physiology Continuous stimulation Stimulation continuous Young Adult 03 medical and health sciences 0302 clinical medicine secondary hyperalgesia medicine Humans nociception burst-like electrical stimulation 030304 developmental biology 0303 health sciences business.industry General Neuroscience Nociceptors Electric Stimulation Touch Perception Hyperalgesia Facilitation Nociceptor Conditioning Female medicine.symptom business Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | J Neurophysiol Journal of neurophysiology, Vol. 123, no.1, p. 323-328 (2020) |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.00675.2019 |
| Popis: | The aim of the present study was to compare the efficacy of burst-like conditioning electrical stimulation vs. continuous stimulation of cutaneous nociceptors for inducing increased pinprick sensitivity in the surrounding unstimulated skin (a phenomenon referred to as secondary hyperalgesia). In a first experiment ( n = 30), we compared the increase in mechanical pinprick sensitivity induced by 50-Hz burst-like stimulation ( n = 15) vs. 5-Hz continuous stimulation ( n = 15) while maintaining constant the total number of stimuli and the total duration of stimulation. We found a significantly greater increase in mechanical pinprick sensitivity in the surrounding unstimulated skin after 50-Hz burst-like stimulation compared with 5-Hz continuous stimulation ( P = 0.013, Cohen’s d = 0.970). Importantly, to control for the different frequency of stimulation, we compared in a second experiment ( n = 40) 5-Hz continuous stimulation ( n = 20) vs. 5-Hz burst-like stimulation ( n = 20), this time while keeping the total number of stimuli as well as the frequency of stimulation identical. Again, we found a significantly greater increase in pinprick sensitivity after 5-Hz burst-like stimulation compared with 5-Hz continuous stimulation ( P = 0.009, Cohen’s d = 0.868). To conclude, our data indicate that burst-like conditioning electrical stimulation is more efficacious than continuous stimulation for inducing secondary hyperalgesia. NEW & NOTEWORTHY Burst-like electrical conditioning stimulation of cutaneous nociceptors is more efficacious than continuous stimulation for inducing heterosynaptic facilitation of mechanical nociceptive input in humans. |
| Databáze: | OpenAIRE |
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