| Autor: |
Jørgen Johansen, Cherice Conley, Hao Dong, Kristen M. Johansen, Ye Jin, Yanming Wang, Diana L. Walker |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Molecular Cell. 4:129-135 |
| ISSN: |
1097-2765 |
| DOI: |
10.1016/s1097-2765(00)80195-1 |
| Popis: |
We have cloned and characterized JIL-1, a novel tandem kinase in Drosophila that associates with the chromosomes throughout the cell cycle. Antibody staining and live imaging of JIL-1-GFP transgenic flies show that JIL-1 localizes to the gene-rich interband regions of larval polytene chromosomes and is upregulated almost 2-fold on the hypertranscribed male X chromosome compared to autosomes. Phylogenetic analysis suggests that JIL-1 together with human MSKs defines a separate family of tandem kinases. That JIL-1 is a functional kinase was demonstrated by autophosphorylation and phosphorylation of histone H3 in vitro. Based on these findings, we propose that JIL-1 may play a role in transcriptional control potentially by regulating chromatin structure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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