Chemical proteomics and its impact on the drug discovery process
| Autor: | Juergen Kast, Qing Miao, Chengcheng Zhang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Proteomics
Drug Process (engineering) media_common.quotation_subject Drug target Computational biology Biology Bioinformatics Biochemistry Mass Spectrometry Small Molecule Libraries Drug Discovery Humans Direct analysis Molecular Biology Fluorescent Dyes media_common Drug discovery Scale (chemistry) Proteins InformationSystems_DATABASEMANAGEMENT Enzymes ComputingMethodologies_PATTERNRECOGNITION Molecular Probes Click Chemistry Identification (biology) Protein Binding |
| Zdroj: | Expert Review of Proteomics. 9:281-291 |
| ISSN: | 1744-8387 1478-9450 |
| DOI: | 10.1586/epr.12.22 |
| Popis: | Despite the rapid growth of postgenomic data and fast-paced technology advancement, drug discovery is still a lengthy and difficult process. More effective drug design requires a better understanding of the interaction between drug candidates and their targets/off-targets in various situations. The ability of chemical proteomics to integrate a multiplicity of disciplines enables the direct analysis of protein activities on a proteome-wide scale, which has enormous potential to facilitate drug target elucidation and lead drug verification. Over recent years, chemical proteomics has experienced rapid growth and provided a valuable method for drug target identification and inhibitor discovery. This review introduces basic concepts and technologies of different popular chemical proteomic approaches. It also covers the essential features and recent advances of each approach while underscoring their potentials in drug discovery and development. |
| Databáze: | OpenAIRE |
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