Nitric oxide and pulmonary arterial pressures in pulmonary hypertension
| Autor: | Serpil C. Erzurum, Daniel Laskowski, Allison J. Janocha, Constance Jennings, Jeffrey P. Hammel, Alejandro C. Arroliga, Roberto F. Machado, Raed A. Dweik, Jacqueline Pyle, Medha Vini Londhe Nerkar |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Time Factors Hypertension Pulmonary Hemodynamics Vasodilation Blood Pressure Pulmonary Artery Nitric Oxide Biochemistry Nitric oxide FEV1/FVC ratio chemistry.chemical_compound Physiology (medical) Internal medicine medicine.artery medicine Humans Prospective Studies Carbon Monoxide Lung Chemistry Middle Aged medicine.disease Pulmonary hypertension Pathophysiology medicine.anatomical_structure Pulmonary artery Cardiology Female |
| Zdroj: | Free radical biologymedicine. 37(7) |
| ISSN: | 0891-5849 |
| Popis: | Decreased production of vasodilator substances such as nitric oxide (NO) has been proposed as important in development of pulmonary arterial hypertension (PAH). We hypothesize that NO measured over time serves as a non invasive marker of severity of PAH and response to therapy. We prospectively and serially measured exhaled NO and carbon monoxide (CO), a vasodilator and anti-inflammatory product of heme oxygenases, in 17 PAH patients in conjunction with hemodynamic parameters over 2 years. Although pulmonary artery pressures and NO were similar in all patients at entry to the study, NO increased in the 12 individuals who survived to complete the study, and correlated with change in pulmonary artery pressures. In contrast, CO did not change or correlate with hemodynamic parameters. Investigation of NO-oxidant reaction products in PAH in comparison to controls suggests that NO synthesis is impaired in the lung and that reactive oxygen species may be involved in the pathophysiology of pulmonary hypertension. Endogenous NO is inversely related to pulmonary artery pressure in PAH, with successful therapy of PAH associated with increase in NO. |
| Databáze: | OpenAIRE |
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