Extended enhancement of corticospinal connectivity with concurrent cortical and peripheral stimulation controlled by sensorimotor desynchronization

Autor: Ulf Ziemann, Alireza Gharabaghi, Dominic Kraus, Robert Guggenberger, Georgios Naros, Maria Teresa Leão
Rok vydání: 2018
Předmět:
Adult
Male
0301 basic medicine
Movement
medicine.medical_treatment
Pyramidal Tracts
Biophysics
Stimulation
lcsh:RC321-571
Young Adult
03 medical and health sciences
Closed-loop stimulation
0302 clinical medicine
Motor imagery
Motor map
medicine
Humans
Paired associative stimulation
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Neurorehabilitation
Brain–computer interface
Brain-robot interface
business.industry
General Neuroscience
Motor Cortex
State-dependent stimulation
Electroencephalography
Evoked Potentials
Motor
Transcranial Magnetic Stimulation
Peripheral stimulation
Peripheral
Transcranial magnetic stimulation
030104 developmental biology
Brain-computer interface
Brain-Computer Interfaces
Imagination
Female
Neurology (clinical)
business
Neuroscience
030217 neurology & neurosurgery
Zdroj: Brain Stimulation, Vol 11, Iss 6, Pp 1331-1335 (2018)
ISSN: 1935-861X
DOI: 10.1016/j.brs.2018.08.012
Popis: Background Pairing cortical and peripheral input during motor imagery (MI)-related sensorimotor desynchronization (ERD) modulates corticospinal excitability at the cortical representation (hotspot) of the imagined movement. Objective To determine the effects of this associative stimulation protocol on the cortical motor map beyond the hotspot. Methods In healthy subjects, peripheral stimulation through passive hand opening by a robotic orthosis and single-pulse transcranial magnetic stimulation to the respective cortical motor representation were applied in a brain-machine interface environment. State-dependency was investigated by concurrent, delayed or non-specific stimulation with respect to ERD in the beta-band (16–22 Hz) during MI of finger extension. Results Concurrent stimulation led to increased excitability of an extended motor map. Delayed and non-specific stimulation led to heterogeneous changes, i.e., opposite patterns of increased excitability in either the center or the periphery of the motor map. Conclusion These results could be instrumental in closed-loop, state-dependent stimulation in the context of neurorehabilitation.
Databáze: OpenAIRE
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