Different Responses of Serum Cationic Trypsinogen to Secretin and Bombesin in Normal Subject and Patients with Chronic Alcoholic Pancreatitis
| Autor: | Carlo Lesi, R. De Mutiis, P. Malaguti, Luisa Zoni, E. Ruffilli |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Trypsinogen Endocrinology Diabetes and Metabolism Stimulation digestive system Secretin chemistry.chemical_compound Endocrinology Cations Internal medicine Internal Medicine medicine Humans Hepatology business.industry Healthy subjects Chronic alcoholic Bombesin Middle Aged Trypsin medicine.disease digestive system diseases Alcoholism Pancreatitis chemistry Chronic Disease Female business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Pancreas. 2:708-714 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-198711000-00015 |
| Popis: | We evaluated the behavior of serum cationic trypsinogen (SCT), an enzyme of solely pancreatic origin, in 30 patients with chronic pancreatitis and 25 healthy subjects as a control, after secretin and bombesin stimulation. After both the stimulations, serum cationic trypsinogen is unable to distinguish between the healthy control subjects and the patients with chronic pancreatitis. On the other hand, after secretin, the enzyme is able to separate chronic pancreatitis patients with different levels of exocrine function insufficiency. It does so with a greater statistical significance than that obtained by the rapid injection of bombesin and equal to that of trypsin into the duodenal juice during duodenal intubation. For these reasons, as well as the absence of any side-effects, secretin is preferred to bombesin stimulation in the evaluation of the exocrine pancreatic function in patients with chronic pancreatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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