Association between oxidative stress and atrial fibrillation
| Autor: | Yongliang Liang, Pratik B. Sandesara, Ayman Samman Tahhan, Yi-An Ko, Wesley T. O'Neal, Dean P. Jones, Arshed A. Quyyumi, Laurence S. Sperling, M. Mazen Gafeer, Matthew L. Topel, Muhammad Hammadah, Heval Mohamed-Kelli, Hiroshi Aida, Nima Ghasemzadeh, Viola Vaccarino, Salim S. Hayek, Kaavya Chivukula, Ayman Alkhoder |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Georgia Time Factors Adolescent 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology Article Coronary artery disease Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation Odds Ratio Prevalence medicine Humans Cysteine Aged Aged 80 and over business.industry Proportional hazards model Hazard ratio Atrial fibrillation Odds ratio Middle Aged medicine.disease Glutathione Confidence interval Surgery Oxidative Stress C-Reactive Protein 030104 developmental biology Heart failure Reactive Oxygen Species Cardiology and Cardiovascular Medicine business Biomarkers Oxidative stress Follow-Up Studies |
| Zdroj: | Heart Rhythm. 14:1849-1855 |
| ISSN: | 1547-5271 |
| Popis: | Background Oxidative stress (OS) may be a key mechanism underlying the development of atrial fibrillation (AF) in experimental studies, but data in humans remain limited. Objective Systemic OS can be estimated by measurements of circulating levels of the aminothiols including glutathione, cysteine, and their oxidized products. We tested the hypothesis that the redox potentials of glutathione (E h GSH) and cysteine will be associated with prevalent and incident AF. Methods Plasma levels of aminothiols were measured in 1439 patients undergoing coronary angiography, of whom 148 (10.3%) had a diagnosis of AF. After a median follow-up of 6.3 years, 104 of 917 patients (11.5%) developed incident AF. Multivariate logistic regression and Cox regression models were used to determine whether OS markers were independent predictors of prevalent and incident AF after adjustment for traditional risk factors, heart failure, coronary artery disease, and high-sensitivity C-reactive protein level. Results For each 10% increase in E h GSH, the odds of prevalent AF was 30% higher (odds ratio [OR] 1.3; 95% confidence interval [CI] 1.1–1.7; P = .02) and 90% higher (OR 1.9; 95% CI 1.3–2.7; P = .004) when the median was used as a cutoff. The E h GSH level above the median was more predictive of chronic AF (OR 4.0; 95% CI 1.3–12.9; P = .01) than of paroxysmal AF (OR 1.7; 95% CI 1.1–2.7; P = .03). Each 10% increase in E h GSH level was associated with a 40% increase in the risk of incident AF (hazard ratio 1.4; 95% CI 1.1–1.7; P = .01). Conclusion Increased OS measured by the redox potentials of glutathione is associated with prevalent and incident AF. Therapies that modulate OS need to be investigated to treat and prevent AF. |
| Databáze: | OpenAIRE |
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