Inositol Polyphosphate Multikinase Signaling: Multifaceted Functions in Health and Disease
| Autor: | Kyunghan Kim, Boah Lee, Seyun Kim, Sehoon Hong, Seung Ju Park |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell signaling
inositol phosphate 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine cell signaling Humans Inositol Phosphatidylinositol Inositol phosphate Molecular Biology 030304 developmental biology chemistry.chemical_classification disease inositol polyphosphate multikinase 0303 health sciences Kinase Autophagy Cell Biology General Medicine Cell biology Phosphotransferases (Alcohol Group Acceptor) chemistry Phosphorylation Minireview Signal transduction 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Molecules and Cells |
| ISSN: | 0219-1032 |
| Popis: | Inositol phosphates are water-soluble intracellular signaling molecules found in eukaryotes from yeasts to mammals, which are synthesized by a complex network of enzymes including inositol phosphate kinases. Among these, inositol polyphosphate multikinase (IPMK) is a promiscuous enzyme with broad substrate specificity, which phosphorylates multiple inositol phosphates, as well as phosphatidylinositol 4,5-bisphosphate. In addition to its catalytic actions, IPMK is known to non-catalytically control major signaling events via direct protein-protein interactions. In this review, we describe the general characteristics of IPMK, highlight its pleiotropic roles in various physiological and pathological conditions, and discuss future challenges in the field of IPMK signaling pathways. |
| Databáze: | OpenAIRE |
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