The Effects of Total Colectomy on Bacterial Translocation in a Model of Acute Pancreatitis
| Autor: | Armagan Gunal, Zafer Kilbas, Ali Kagan Coskun, Abdullah Kilic, Mustafa Öner Menteş, Ali Harlak, Taner Yigit, Rahman Şenocak, Orhan Kozak |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
business.industry Secondary infection medicine.medical_treatment medicine.disease Gastroenterology Small intestine medicine.anatomical_structure Internal medicine medicine Pancreatic Infection Pancreatitis Acute pancreatitis Original Article Surgery Pancreas business Saline Colectomy |
| Zdroj: | Indian Journal of Surgery. 77:412-418 |
| ISSN: | 0973-9793 0972-2068 |
| Popis: | Prevention of secondary infection is currently the main goal of treatment for acute necrotizing pancreatitis. Colon was considered as the main origin of secondary infection. Our aim was to investigate whether prophylactic total colectomy would reduce the rate of bacterial translocation and infection of pancreatic necrosis. Forty-two Sprague–Dawley rats were used. Pancreatitis was created by ductal infusion of sodium taurocholate. Rats were divided into four groups: group-1, laparotomy + pancreatic ductal infusion of saline; group-2, laparotomy + pancreatic ductal infusion of sodium taurocholate; group-3, total colectomy + pancreatic ductal infusion of saline; and group-4, total colectomy + pancreatic ductal infusion of sodium taurocholate. Forty-eight hours later, tissue and blood samples were collected for microbiological and histopathological analysis. Total colectomy caused small bowel bacterial overgrowth with gram-negative and gram-positive microorganisms. Bacterial count of gram-negative rods in the small intestine and pancreatic tissue in rats with colectomy and acute pancreatitis were significantly higher than in rats with acute pancreatitis only (group-2 versus group-4; small bowel, p = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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