Application of integrative genomics and systems biology to conventional and in-vitro reproductive traits in cattle
| Autor: | Pamela A. Alexandre, Hanne Skovsgaard Pedersen, Poul Hyttel, Eduardo M. Razza, Gerson A. Oliveira Júnior, Gianluca Mazzoni, Henrik Callesen, Haja N. Kadarmideen, Marcelo Fábio Gouveia Nogueira, José Bento Sterman Ferraz |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
General Veterinary business.industry Systems biology biomarkers Computational biology Biology Integrative genomics In vitro Biotechnology reproduction 03 medical and health sciences 030104 developmental biology cattle systems biology cattle biomarkers data integration Animal Science and Zoology business data integration IVP |
| Zdroj: | Mazzoni, G, Pedersen, H S, de Oliveira Junior, G A, Alexandre, P, Razza, E M, Callesen, H, Hyttel, P, Nogueira, M FG, Ferraz, J B S & Kadarmideen, H 2017, ' Application of integrative genomics and systems biology to conventional and in-vitro reproductive traits in cattle ', Animal Reproduction, vol. 14, no. 3, pp. 507-513 . https://doi.org/10.21451/1984-3143-AR993 |
| DOI: | 10.21451/1984-3143-AR993 |
| Popis: | Assisted reproductive technologies (ARTs) have a strong impact on breeding especially when coupled with genomic selection (GS). The routine implementation of in vitro production (IVP) and GS of embryos before embryo transfer (ET) in breeding companies is not yet possible. Improvement of oocyte donor and embryo recipient quality is needed to make realistic a commercialization of these procedures in the near future. A better understanding of both biological mechanisms and molecular markers associated to IVP-ET related traits is necessary to improve the prediction of donor and recipient cow quality for IVP procedures. The huge amount of data generated from high throughput technologies has a tremendous impact in the search for biomarkers of complex traits. This paper reviews integrative genomics and systems biology approaches as applied to both Bos indicus and Bos taurus cattle reproduction by both conventional and ARTs such as OPU-IVP. The integration of systems biology information across different biological layers generates a complete view of the different molecular networks that control complex traits and can provide a strong contribution to the understanding of traits related to ARTs. |
| Databáze: | OpenAIRE |
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