Graft-versus-host disease: How to translate new insights into new therapeutic strategies
| Autor: | Julie M. Vose, Marcel P. Devetten |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
T-Lymphocytes
Graft vs Host Disease Disease Lymphocyte Activation Major histocompatibility complex Graft-versus-host disease Proinflammatory cytokine Major Histocompatibility Complex Humans Medicine Cytotoxicity Alemtuzumab Extracorporeal photophoresis Bone Marrow Transplantation Sirolimus Inflammation Transplantation biology business.industry Hematology medicine.disease MMR Pathophysiology ATG Pento-statin surgical procedures operative Lymphocyte Transfusion Immunology biology.protein Stem cell transplant T cell depletion business Immunosuppressive Agents medicine.drug |
| Zdroj: | Biology of Blood and Marrow Transplantation. 10:815-825 |
| ISSN: | 1083-8791 |
| Popis: | Graft-versus-host disease occurs when transplanted donor-derived T lymphocytes recognize major or minor histocompatibility complex proteins and their associated peptides expressed by recipient antigen-presenting cells. A widely accepted paradigm for the pathophysiology of acute GVHD is based on the existence of 3 sequential steps: (1) injury to the host environment (as would occur during conditioning regimens); (2) donor T-cell activation, proliferation, and differentiation; and (3) damage to the target tissue caused by either cytotoxicity or indirectly by inflammatory cytokines. In order to reduce the incidence of GVHD, recent studies have focused on methods of prophylaxis as well as novel treatments for established GVHD. We review each phase in the development of acute GVHD and discuss recently developed interventions aimed to prevent or treat GVHD by interfering with these pathways. |
| Databáze: | OpenAIRE |
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