Double-blind clinical study comparing alprazolam and doxepin in primary unipolar depression
| Autor: | S. Diricq, J. Owieczka, A. Dumortier, E. Jansegers, Marc Ansseau, R. De Buck, G. Stellamans, M. Bogaerts, L. Botte, C. Ansoms, G. Beckers |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Adolescent law.invention Clinical study Double blind Benzodiazepines Double-Blind Method Randomized controlled trial law medicine Humans Depression (differential diagnoses) Aged Random allocation Clinical Trials as Topic Depressive Disorder Psychological Tests Alprazolam Dose-Response Relationship Drug Therapeutic effect Middle Aged Doxepin Psychiatry and Mental health Clinical Psychology Anti-Anxiety Agents Anesthesia Female Psychology medicine.drug |
| Zdroj: | Journal of Affective Disorders. 7:287-296 |
| ISSN: | 0165-0327 |
| Popis: | The therapeutic effect and safety of alprazolam and doxepin were studied in 126 outpatients suffering from primary unipolar depression. The 6-week study was double-blind with a random allocation of treatment. Patients were treated with a flexible dose of 1.0-4.5 mg of alprazolam and 50-225 mg of doxepin per day. The mean final doses were 2.7 mg for alprazolam and 137.5 mg for doxepin. The results indicate that alprazolam and doxepin were equally efficacious. The incidence of side-effects was lower in the alprazolam treatment group. |
| Databáze: | OpenAIRE |
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