Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue
| Autor: | Agnieszka Ścibior, Irmina Niedźwiecka, Dorota Gołębiowska |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Aging Article Subject Iron chemistry.chemical_element Pharmacology Protective Agents Biochemistry Lipid peroxidation chemistry.chemical_compound Magnesium Sulfate In vivo Malondialdehyde Animals lcsh:QH573-671 Rats Wistar Magnesium lcsh:Cytology Vanadium Cell Biology General Medicine Hepatic tissue Independent action In vitro Rats chemistry Liver Rat liver Lipid Peroxidation Subcellular Fractions Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2013 (2013) |
| ISSN: | 1942-0900 |
| DOI: | 10.1155/2013/802734 |
| Popis: | The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate- (SMV-) induced lipid peroxidation (LPO) underin vivoandin vitroconditions was studied. The 18-week SMV intoxication (Group II, 0.125 /mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver, compared with the control (Group I) and MS-supplemented animals (Group III, 0.06 /mL). Coadministration of SMV with MS (Group IV, SMV-MS) caused a return of the MDA level to the control value range. The effect seems to result from the -independent action and its antagonistic interaction with . Thein vitrotreatment of liver supernatants (LS) obtained from all the tested animals groups with selected exogenous concentrations of or exhibited enhanced MDA production, compared with spontaneously formed MDA. It also showed -stimulating effect on LPO (LS I, Group I) and revealed that the changes in the MDA generation in LS IV (Group IV) might have resulted from the synergistic interactions of with and and from the antagonistic interactions of with and . The findings allow a suggestion that adequate Mg intake for a specific period in the conditions of SMV exposure may prevent V-induced LPO in the liver. |
| Databáze: | OpenAIRE |
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