Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge
| Autor: | Jaap Goudsmit, Jeroen Tolboom, Eirikur Saeland, Liesbeth Dekking, Freek Cox, Nicole Hafkemeijer, Anna Roos, Matthijs Baart, Koert J. Stittelaar, Katarina Radosevic |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Influenza vaccine
medicine.medical_treatment lcsh:Medicine Cross Reactions Biology Antibodies Viral Virus Replication medicine.disease_cause Virus Viral Matrix Proteins Mice Adjuvants Immunologic Orthomyxoviridae Infections Pandemic Influenza A virus medicine Animals lcsh:Science Multidisciplinary lcsh:R Ferrets virus diseases Virology Influenza A virus subtype H5N1 Virosome Vaccines Virosome Disease Models Animal Immunization Influenza Vaccines Immunology lcsh:Q Female Adjuvant Research Article |
| Zdroj: | PLoS ONE, 10(9). Public Library of Science PLoS ONE, 10(9) PLoS ONE PLoS ONE, Vol 10, Iss 9, p e0135723 (2015) |
| Popis: | There is a constant threat of zoonotic influenza viruses causing a pandemic outbreak in humans. It is virtually impossible to predict which virus strain will cause the next pandemic and it takes a considerable amount of time before a safe and effective vaccine will be available once a pandemic occurs. In addition, development of pandemic vaccines is hampered by the generally poor immunogenicity of avian influenza viruses in humans. An effective pre-pandemic vaccine is therefore required as a first line of defense. Broadening of the protective efficacy of current seasonal vaccines by adding an adjuvant may be a way to provide such first line of defense. Here we evaluate whether a seasonal trivalent virosomal vaccine (TVV) adjuvated with the saponin-based adjuvant Matrix-M (MM) can confer protection against avian influenza H5 and H7 virus strains in mice and ferrets. We demonstrate that mice were protected from death against challenges with H5N1 and H7N7, but that the protection was not complete as evidenced by severe clinical signs. In ferrets, protection against H7N9 was not observed. In contrast, reduced upper and lower respiratory tract viral loads and reduced lung pathology, was achieved in H5N1 challenged ferrets. Together these results suggest that, at least to some extent, Matrix-M adjuvated seasonal virosomal influenza vaccine can serve as an interim measure to decrease morbidity and mortality associated with a pandemic outbreak. |
| Databáze: | OpenAIRE |
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