Salicylic acid-based pH-sensitive hydrogels as potential oral insulin delivery systems

Autor:	Kathryn E. Uhrich, Bahar Demirdirek
Rok vydání:	2015
Předmět:	Drug Compounding medicine.medical_treatment Acrylic Resins Administration Oral Pharmaceutical Science Pharmacology Mice chemistry.chemical_compound Drug Delivery Systems Polyanhydrides Diabetes Mellitus medicine Animals Hypoglycemic Agents Insulin Acrylic acid Drug Carriers Chromatography technology industry and agriculture Hydrogels Hydrogen-Ion Concentration Biodegradable polymer Drug Combinations Drug Liberation Cross-Linking Reagents chemistry Self-healing hydrogels NIH 3T3 Cells Swelling medicine.symptom Salicylic Acid Drug carrier Salicylic acid
Zdroj:	Journal of Drug Targeting. 23:716-724
ISSN:	1029-2330 1061-186X
DOI:	10.3109/1061186x.2015.1073293
Popis:	Salicylic acid (SA)-based physically crosslinked pH-sensitive hydrogels were developed for oral insulin delivery using various ratios of salicylate-based poly(anhydride-ester) and poly(acrylic acid) (PAA). Pore size, swelling behavior, insulin loading, insulin and SA release rates of the gels were varied by changing PAA concentration. About 50% of insulin was incorporated within all of the hydrogels, with about 4-8% of insulin released in acidic conditions (pH 1.2) over 2 h. In pH simulating the intestine (pH 6.8), 90% of the insulin and 70% of SA were released within 24 h from the hydrogel system. These results suggest that hydrogels enable pH-dependent protein delivery and can be used for oral insulin and SA delivery to benefit diabetes patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87bcbba34c6566c68aae10dde952d8e https://doi.org/10.3109/1061186x.2015.1073293 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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