Effects of nutritional supplementation on the appetite and energy intake responses to IV cholecystokinin in older adults
| Autor: | Michael Horowitz, Kamilia Tai, Ian Chapman, Judith M. Wishart, Christine Feinle-Bisset |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aging medicine.medical_specialty Nutritional Supplementation Normal diet medicine.medical_treatment media_common.quotation_subject Appetite digestive system Internal medicine Blood plasma medicine Humans Single-Blind Method Infusions Intravenous Saline General Psychology Aged Cholecystokinin media_common Aged 80 and over Meal Nutrition and Dietetics business.industry digestive oral and skin physiology Dietary Fats Endocrinology Dietary Supplements Female Energy Intake business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Appetite. 55:473-477 |
| ISSN: | 0195-6663 |
| DOI: | 10.1016/j.appet.2010.08.010 |
| Popis: | Human aging is associated with a reduction in appetite and food intake. Increased activity of the satiety hormone, cholecystokinin (CCK), may be partly responsible. This study aimed to determine whether an increase in fat and energy intake modifies the suppressive effects of CCK-8 on appetite and energy intake. Fourteen healthy older adults completed three separate dietary periods, a 14-day and a 7-day normal diet (ND; 8272 ± 480 kJ/day; 35% fat), and a 14-day high-fat diet (HFD; 11,642 ± 414 kJ/day; 43% fat), in randomised order. Immediately following each diet, subjects received, in single-blinded fashion, a 30-min intravenous infusion of either CCK-8 (1.5 ng/kg/min) (ND-CCK, HFD-CCK) or 0.9% saline (ND-SAL), the latter following only ND. Plasma CCK concentrations, appetite responses and energy intake at a buffet meal were determined. Energy intake at the buffet meal was higher on the ND-SAL study day (3349 ± 224 kJ), when compared with either ND-CCK (3023 ± 317 kJ) or HFD-CCK (2905 ± 316 kJ). The suppression of energy intake by CCK-8 infusion did not differ between the two diets. We conclude that suppression of energy intake by exogenous CCK-8 does not appear to be attenuated by incorporation of supplemental high-energy, high-fat drinks in the diet of healthy older adults. |
| Databáze: | OpenAIRE |
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