Development of an appropriate simple suspension method for valganciclovir medication

Autor: Atsushi Ogawa, Yasuyuki Masaoka, Soichiro Ushio, Ryo Kikuoka, Yoshihisa Kitamura, Yudai Wada, Yoichi Kawasaki, Toshiaki Sendo, Satoru Esumi
Rok vydání: 2020
Předmět:
Zdroj: Journal of Pharmaceutical Health Care and Sciences, Vol 6, Iss 1, Pp 1-7 (2020)
Journal of Pharmaceutical Health Care and Sciences
ISSN: 2055-0294
DOI: 10.1186/s40780-020-00172-w
Popis: Background Valganciclovir (VGC) is essential for preventing cytomegalovirus infections after transplants in adult and pediatric patients. In pediatric patients, VGC tablets have to be pulverized so that they can be delivered via nasogastric tubes. The “simple suspension method” is usually used to suspend tablets in hot water in Japan. However, the optimal suspension conditions and metering methods for preparing VGC suspensions using the simple suspension method are unclear. The purpose of this study was to clarify these issues. Methods VGC tablets were suspended in water (initial water temperature: 25 °C or 55 °C) using the simple suspension method. The residual rate of VGC after it had been suspended in hot water was determined using HPLC. In addition, the suspended solution was passed through 6, 8, and 12 Fr. gavage tubes. The VGC concentrations of suspensions produced using different preparation methods were also determined using HPLC. Results Cracking the surfaces of VGC tablets and suspending them in water at an initial temperature of 55 °C was effective at dissolving the tablets. The VGC concentration of the suspension remained stable for at least 80 min. Furthermore, the VGC concentration remained stable for 48 h during cold dark storage. Cracking the surfaces of VGC tablets could be a more effective metering method than preparing powder from VGC tablets. In addition, little VGC remained in 6, 8, or 12 Fr. gavage tubes after VGC solution was passed through them. Conclusion The amount of VGC should be measured carefully when preparing VGC solutions using the simple suspension method.
Databáze: OpenAIRE
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