False Lumen Flow Patterns and their Relation with Morphological and Biomechanical Characteristics of Chronic Aortic Dissections. Computational Model Compared with Magnetic Resonance Imaging Measurements
| Autor: | Paula A. Rudenick, Patrick Segers, Hug Cuéllar, David Garcia-Dorado, Victor Pineda, Arturo Evangelista, Bart Bijnens |
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| Přispěvatelé: | Institut Català de la Salut, [Rudenick PA] Physense, Universitat Pompeu Fabra, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Segers P] Biofluid, Tissue and Solid Mechanics for Medical Applications, Institute Biomedical Technology, Ghent University, Ghent, Belgium. [Pineda V, Cuellar H, García-Dorado D, Evangelista A] Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Bijnens BH] Physense, Universitat Pompeu Fabra, Barcelona, Spain. ICREA, Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Respiratory System
Hemodynamics lcsh:Medicine 02 engineering and technology 030204 cardiovascular system & hematology Stiffness Diagnostic Radiology Aortic aneurysm 0302 clinical medicine Diastole Thoracic Diaphragm Medicine and Health Sciences lcsh:Science Aorta Flow Rate Multidisciplinary medicine.diagnostic_test enfermedades cardiovasculares::enfermedades vasculares::aneurisma::aneurisma de la aorta [ENFERMEDADES] Radiology and Imaging Physics Models Cardiovascular Classical Mechanics Anatomy Hematology Middle Aged Magnetic Resonance Imaging Diaphragm (structural system) Aortic Aneurysm Cardiovascular Diseases::Vascular Diseases::Aneurysm::Aneurysm Dissecting [DISEASES] Physical Sciences Blood Flow Velocity Research Article Adult Imaging Techniques Systole 0206 medical engineering Materials Science Material Properties Cardiology Fluid Mechanics Research and Analysis Methods Continuum Mechanics 03 medical and health sciences Vascular Stiffness Diagnostic Medicine medicine.artery medicine Mechanical Properties Humans diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] enfermedades cardiovasculares::enfermedades vasculares::aneurisma::aneurisma disecante [ENFERMEDADES] Fluid Flow Other subheadings::Other subheadings::/diagnostic imaging [Other subheadings] Aged Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] business.industry lcsh:R Biology and Life Sciences Magnetic resonance imaging Otros calificadores::Otros calificadores::/diagnóstico por imagen [Otros calificadores] Fluid Dynamics medicine.disease 020601 biomedical engineering Cardiovascular Diseases::Vascular Diseases::Aneurysm::Aortic Aneurysm [DISEASES] Aneurismes aòrtics - Imatgeria per ressonància magnètica Aortic Dissection Flow (mathematics) Cardiovascular Anatomy Blood Vessels lcsh:Q business |
| Zdroj: | PLoS ONE Scientia PLOS ONE PLoS ONE, Vol 12, Iss 1, p e0170888 (2017) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| ISSN: | 1932-6203 |
| Popis: | Aortic wall stiffness, tear size and location and the presence of abdominal side branches arising from the false lumen (FL) are key properties potentially involved in FL enlargement in chronic aortic dissections (ADs). We hypothesize that temporal variations on FL flow patterns, as measured in a cross-section by phase-contrast magnetic resonance imaging (PC-MRI), could be used to infer integrated information on these features. In 33 patients with chronic descending AD, instantaneous flow profiles were quantified in the FL at diaphragm level by PC-MRI. We used a lumped-parameter model to assess the changes in flow profiles induced by wall stiffness, tear size/location, and the presence of abdominal side branches arising from the FL. Four characteristic FL flow patterns were identified in 31/33 patients (94%) based on the direction of flow in systole and diastole: BA = systolic biphasic flow and primarily diastolic antegrade flow (n = 6); BR = systolic biphasic flow and primarily diastolic retrograde flow (n = 14); MA = systolic monophasic flow and primarily diastolic antegrade flow (n = 9); MR = systolic monophasic flow and primarily diastolic retrograde flow (n = 2). In the computational model, the temporal variation of flow directions within the FL was highly dependent on the position of assessment along the aorta. FL flow patterns (especially at the level of the diaphragm) showed their characteristic patterns due to variations in the cumulative size and the spatial distribution of the communicating tears, and the incidence of visceral side branches originating from the FL. Changes in wall stiffness did not change the temporal variation of the flows whereas it importantly determined intraluminal pressures. FL flow patterns implicitly codify morphological information on key determinants of aortic expansion in ADs. This data might be taken into consideration in the imaging protocol to define the predictive value of FL flows. The research leading to these results has received funding from the Subprograma de Proyectos de Investigación en Salud (FIS), Instituto de Salud Carlos III, Spain (ref. PI108/0608, PI11/01709); the Programa de ayudas destinadas a universidades, centros de investigación y fundaciones hospitalarias para la contratación de personal investigador novel (FI-DGR 2011), Spain; and the EU FP7 for research, technological development and demonstration under grant agreement VP2HF (no 611823). All authors have reported that they have no relationships relevant to the contents of this paper to disclose. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Databáze: | OpenAIRE |
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