Neural substrate of cognitive theory of mind impairment in amyotrophic lateral sclerosis

Autor: Laurence Carluer, Francis Eustache, Alice Pélerin, Audrey Mondou, Mickaël Laisney, Fausto Viader, Béatrice Desgranges, Marie-Sonia Buhour
Přispěvatelé: Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychologie et imagerie de la mémoire humaine (NIMH), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
Rok vydání: 2014
Předmět:
Adult
Male
medicine.medical_specialty
Neural substrate
Cognitive Neuroscience
Theory of Mind
Experimental and Cognitive Psychology
Audiology
Neuropsychological Tests
050105 experimental psychology
03 medical and health sciences
Executive Function
0302 clinical medicine
Cognition
Social cognition
Theory of mind
medicine
Humans
0501 psychology and cognitive sciences
Amyotrophic lateral sclerosis
Social Behavior
ComputingMilieux_MISCELLANEOUS
Aged
Aged
80 and over
Supplementary motor area
[SCCO.NEUR]Cognitive science/Neuroscience
05 social sciences
Amyotrophic Lateral Sclerosis
Middle Aged
medicine.disease
Executive functions
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
[SCCO.PSYC]Cognitive science/Psychology
Female
Psychology
Cognition Disorders
Neuroscience
030217 neurology & neurosurgery
Executive dysfunction
Zdroj: Cortex
Cortex, Elsevier, 2015, 65, pp.19-30. ⟨10.1016/j.cortex.2014.12.010⟩
ISSN: 1973-8102
0010-9452
DOI: 10.1016/j.cortex.2014.12.010⟩
Popis: We now know that amyotrophic lateral sclerosis (ALS) is not restricted to the motor system. Indeed, a large proportion of patients with ALS exhibit cognitive impairment, especially executive dysfunction or language impairment. Although researchers have recently turned their attention to theory of mind (ToM) in ALS, only five studies have been performed so far, and they reported somewhat contradictory results. Moreover, the neural basis of the potential ToM deficit in ALS remains largely unknown. The present study was therefore designed to clarify whether a cognitive ToM deficit is indeed associated with ALS, specify the putative link between cognitive ToM deficits and executive dysfunction in ALS, and identify the dysfunctional brain regions responsible for any social cognition deficits. We investigated cognitive ToM and executive functions in a group of 23 patients with ALS and matched healthy controls, using an original false-belief task and a specially designed battery of executive tasks. We also performed an (18)F-fluorodeoxyglucose positron emission tomography examination. Results confirmed the presence of cognitive ToM deficits in patients compared with controls, and revealed significant correlations between ToM and executive functions, although the cognitive ToM deficit persisted when a composite executive function score was entered as a covariate. Using statistical parametric mapping, we calculated positive correlations between tracer uptake and false-belief scores on a voxel-by-voxel basis in the patient sample. Results showed that the cognitive ToM deficit correlated with the dorsomedial and dorsolateral prefrontal cortices, as well as the supplementary motor area. Our findings provide compelling clinical and imaging evidence for the presence of a genuine cognitive ToM deficit in patients with ALS.
Databáze: OpenAIRE
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