Dual Stimuli-Responsive Block Copolymers with Adjacent Redox- and Photo-Cleavable Linkages for Smart Drug Delivery
| Autor: | Ming-Fong Tsai, Li-Fang Wang, Yugendhar Soorni, Yu-Lun Lo, Zi-Xian Liao, Chin Hsu |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Polymers Reducing agent Bioengineering 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Micelle Biomaterials Drug Delivery Systems Amphiphile Materials Chemistry Copolymer Micelles Drug Carriers Aqueous solution Chemistry Atom-transfer radical-polymerization 021001 nanoscience & nanotechnology 0104 chemical sciences Polymerization Doxorubicin 0210 nano-technology Oxidation-Reduction Linker |
| Zdroj: | Biomacromolecules. 21:3342-3352 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.0c00773 |
| Popis: | A novel dual-stimuli cleavable linker containing adjacent UV light-sensitive o-nitrobenzyl ester and GSH-responsive disulfide bonds was first designed and synthesized to increase the responsivity to external stimuli. The functionalized linker was then utilized to prepare a dual-responsive amphiphilic block copolymer using ring-opening polymerization and atom transfer radical polymerization. The copolymer formed a micelle in an aqueous solution and showed dual-stimuli responses including photo-mediated cleavage under UV light irradiation at 365 nm as well as reduction-responsive degradation in the presence of a reducing agent. The micelle was nontoxic against three cell lines and majorly internalized via clathrin-mediated endocytosis. Doxorubicin (Dox) was loaded in the hydrophobic core of the micelle. Enhancement of a cell-killing effect against A549 cells was clearly observed in the Dox-encapsulated micelle when exposed to UV light. |
| Databáze: | OpenAIRE |
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