Phagocytosis of Hybrid Molecular Nanosomal Compositions Containing Oxidized Dextrans Conjugated with Isonicotinic Acid Hydrazide by Macrophages
| Autor: | A. V. Troitsky, D. A. Iljine, M. V. Zaikovskaja, E. G. Ufimceva, N. G. Luzgina, E. P. Gulyaeva, S. A. Arkhipov, T. N. Bistrova, V. A. Shkurupy, E. S. Akhramenko |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Phagocytosis Conjugated system Antituberculous drugs Isonicotinic acid Hydrazide General Biochemistry Genetics and Molecular Biology Nanocomposites Mice chemistry.chemical_compound Isoniazid Animals Organic chemistry Cells Cultured Mice Inbred BALB C Chemistry Permanganate Dextrans General Medicine Dextran Liposomes Macrophages Peritoneal Oxidation-Reduction Intracellular Nuclear chemistry |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 148:874-876 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-010-0839-x |
| Popis: | We studied phagocytic activity of macrophages towards hybrid molecular nanosomal compositions consisting of 150-800-nm nanoliposomes containing oxidized dextrans with a molecular weight of 35 and 60 kDa obtained by chemical ("permanganate") and radiochemical oxidation of dextran conjugated with isonicotinic acid hydrazide (dextrazides, intracellular prolonged antituberculous drugs). Phagocytic activity of macrophages towards hybrid molecular nanosomal compositions containing dextrazides obtained by chemical oxidation of dextrans is higher than activity towards hybrid molecular nanosomal compositions containing dextrazides prepared by radiochemical oxidation and depends on the size of hybrid molecular nanosomal compositions and molecular weight of oxidized dextrans. |
| Databáze: | OpenAIRE |
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