Microarray data and pathway analyses for primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells
| Autor: | Cynthia G. Sawyez, Nica M. Borradaile, Alexandra M. Hetherington |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Cirrhosis Liver cytology Biology lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences 0302 clinical medicine Fibrosis NAFLD Gene expression medicine Hepatocyte lcsh:Science (General) Data Article Multidisciplinary Microarray analysis techniques medicine.disease 030104 developmental biology medicine.anatomical_structure Liver 030220 oncology & carcinogenesis Hepatocellular carcinoma Stellate cell Cancer research Hepatic stellate cell lcsh:R858-859.7 lcsh:Q1-390 |
| Zdroj: | Data in Brief Data in Brief, Vol 10, Iss C, Pp 385-389 (2017) |
| ISSN: | 2352-3409 |
| Popis: | As nonalcoholic fatty liver disease progresses to end-stage diseases, including fibrosis, cirrhosis and hepatocellular carcinoma, fibrotic activated hepatic stellate cells and cancerous epithelial cells can become abundant, changing the cellular composition of this organ. Despite potentially residing within the same diseased tissue, direct comparisons of global gene expression between activated hepatic stellate cells and hepatocellular carcinoma cells are lacking. Here we provide data collected using Affymetrix GeneChip microarrays to identify differential gene expression in cultured primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells. The dataset includes many genes involved in intermediary metabolism which were investigated in greater depth in our associated article (A.M. Hetherington, C.G. Sawyez, E. Zilberman, A.M. Stoianov, D.L. Robson, J.M. Hughes-Large, et al., 2016) [1]. Pathway analyses of known protein coding genes down-regulated or up-regulated by greater than 2.0-fold are also provided. |
| Databáze: | OpenAIRE |
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