Remote Oxidation of Aliphatic C-H Bonds in Nitrogen-Containing Molecules

Autor:	Kaibo Feng, Joseph R. Clark, Jennifer M. Howell, Louis J. Trzepkowski, M. Christina White
Rok vydání:	2015
Předmět:	Primary (chemistry) Nitrogen chemistry.chemical_element General Chemistry Biochemistry Catalysis Carbon Article Colloid and Surface Chemistry chemistry Organic chemistry Molecule Amine gas treating Lewis acids and bases Brønsted–Lowry acid–base theory Oxidation-Reduction Hydrogen
Zdroj:	Journal of the American Chemical Society. 137(46)
ISSN:	1520-5126
Popis:	Nitrogen heterocycles are ubiquitous in natural products and pharmaceuticals. Herein, we disclose a nitrogen complexation strategy that employs a strong Brønsted acid (HBF4) or an azaphilic Lewis acid (BF3) to enable remote, non-directed C(sp3)—H oxidations of tertiary (3°), secondary (2°), and primary (1°) amine- and pyridine- containing molecules with tunable iron catalysts. Imides resist oxidation and promote remote functionalization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a871f9ba756f5454b6376127d3fda16b https://pubmed.ncbi.nlm.nih.gov/26536374 Zobrazit plný text záznamu