Suppression of delayed-type hypersensitivity and IgE antibody responses to ovalbumin by intranasal administration of Escherichia coli heat-labile enterotoxin B subunit-conjugated ovalbumin
| Autor: | Shinichi Tamura, Takeshi Kurata, Chikara Aizawa, Emiko Hatori, Takashi Tsuruhara |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Ovalbumin
Bacterial Toxins Heat-labile enterotoxin medicine.disease_cause Microbiology Enterotoxins Mice Allergen Antigen Oral administration Escherichia coli Immune Tolerance medicine Animals Hypersensitivity Delayed Administration Intranasal Mice Inbred BALB C Vaccines Conjugate General Veterinary General Immunology and Microbiology biology Escherichia coli Proteins Public Health Environmental and Occupational Health Immunoglobulin E respiratory system Bacterial vaccine Infectious Diseases Delayed hypersensitivity Bacterial Vaccines biology.protein Molecular Medicine Female Nasal administration |
| Zdroj: | Vaccine. 15:225-229 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(96)00135-1 |
| Popis: | Oral administration of a small amount of antigen conjugated cholera toxin B subunit is known to induce tolerance to the antigen. In the present experiments, whether nasal administration of allergen conjugated to Escherichia coli heat-labile toxin B subunit (LTB) induced tolerance was examined in BALB/c mice. A single administration of a small amount of LTB-coupled ovalbumin (OVA) suppressed the induction of delayed-type hypersensitivity and IgE antibody responses to OVA which was administered parenterally after nasal administration of LTB-coupled OVA. The antigen-specific suppression was abrogated by the addition of the holotoxin to LTB-coupled OVA. The suppression, induced by nasal administration with a small amount of allergen conjugated to a mucosa-binding molecule, may be applicable for preventing the development of allergy. |
| Databáze: | OpenAIRE |
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