miRNA expression profiling divides follicular dendritic cell sarcomas into two groups, related to fibroblasts and myopericytomas or Castleman's disease
| Autor: | Luisa Lorenzi, Claudio Agostinelli, Soo Jeong Portscher-Kim, Martin-Leo Hansmann, Holger Hackstein, Claudia Döring, Silvia Lonardi, Jay Mehta, Sylvia Hartmann, José Cabeçadas, Stefano Pileri, Fabio Facchetti, Stefan Kippenberger, Daniel Martinez, Ingrid Simonitsch-Klupp, Elias Campo, Anita Borges, Fabio Fuligni, Pier Paolo Piccaluga |
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| Přispěvatelé: | Hartmann, Sylvia, Döring, Claudia, Agostinelli, Claudio, Portscher-Kim, Soo-Jeong, Lonardi, Silvia, Lorenzi, Luisa, Fuligni, Fabio, Martinez, Daniel, Mehta, Jay, Borges, Anita, Hackstein, Holger, Kippenberger, Stefan, Piccaluga, Pier Paolo, Simonitsch-Klupp, Ingrid, Cabeçadas, José, Campo, Elia, Facchetti, Fabio, Pileri, Stefano A., Hansmann, Martin-Leo |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cancer Research Adolescent Cell of origin BRAF Follicular dendritic cell sarcoma Follicular dendritic cells miRNA profiling Podoplanin Oncology Dendritic Cell Sarcoma Follicular Biology 03 medical and health sciences Young Adult 0302 clinical medicine microRNA medicine Biomarkers Tumor Humans Aged Aged 80 and over Castleman Disease Gene Expression Profiling Mesenchymal stem cell Fibroblasts Middle Aged medicine.disease Microarray Analysis Immunohistochemistry Gene expression profiling MicroRNAs 030220 oncology & carcinogenesis Female Sarcoma Follicular dendritic cell Dendritic Cells Follicular 030215 immunology |
| Zdroj: | European journal of cancer (Oxford, England : 1990). 64 |
| ISSN: | 1879-0852 |
| Popis: | Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumours, which are fatal in 20% of the patients and usually occur in secondary lymphoid organs or extranodal localizations. Due to the rareness of these tumours, only few studies have been conducted on molecular level. In the present study, we performed microRNA (miRNA) profiling of 31 FDC sarcomas and identified two subgroups, one with high miRNA expression and the other group with low miRNA expression levels. The first group showed a strong similarity to fibroblasts and myopericytomas, whereas the second group was more closely related to FDCs from Castleman's disease. Both groups showed important differences compared with myeloid-derived dendritic cells, confirming mesenchymal origin of FDCs and their derived sarcomas. The two FDC sarcoma groups did not differ on morphological grounds, mitotic activity or BRAF mutation status. However, patients of group I presented a tendency to a shorter overall survival and more frequent podoplanin expression by immunohistochemistry. The importance of these newly recognized FDC sarcoma subgroups in terms of clinical behaviour and therapeutic implications should be assessed in a larger cohort in future studies. |
| Databáze: | OpenAIRE |
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