Rapid full engraftment and successful immune reconstitution after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in Omenn syndrome

Autor:	Anna Mordel, Marcin Majka, Ewa Lesko, Wojciech Czogała, Danuta Kowalczyk, Marek Zembala, Oktawiusz Wiecha, Szymon Skoczeń, Aleksandra Krasowska-Kwiecień, Jolanta Gozdzik
Rok vydání:	2009
Předmět:	Male Human cytomegalovirus Transplantation Conditioning medicine.medical_treatment Hematopoietic stem cell transplantation Antiviral Agents hemic and lymphatic diseases medicine Humans Transplantation Homologous Eosinophilia Lymphocytes Bone Marrow Transplantation Transplantation Severe combined immunodeficiency business.industry Siblings Hematopoietic Stem Cell Transplantation Infant medicine.disease Omenn syndrome Treatment Outcome surgical procedures operative medicine.anatomical_structure Immune System Cytomegalovirus Infections Pediatrics Perinatology and Child Health Immunology Severe Combined Immunodeficiency Bone marrow Stem cell medicine.symptom business Immunosuppressive Agents
Zdroj:	Pediatric Transplantation. 13:760-765
ISSN:	1399-3046 1397-3142
DOI:	10.1111/j.1399-3046.2008.01020.x
Popis:	OS is a variant of SCID characterized by generalized erythroderma, alopecia, eosinophilia, and elevated IgE levels. It is fatal unless treated with allogeneic HSCT, which is the only curative approach. However, treatment related complications and graft rejection are major obstacles to the success of treatment. In this report, we describe a patient with OS, complicated by prolonged cytomegalovirus infection, successfully treated by reduced intensity conditioning allogeneic HSCT from sibling donor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86df96b2b629f241fb3ee1ff8f11ae9 https://doi.org/10.1111/j.1399-3046.2008.01020.x Zobrazit plný text záznamu Plný text ve formátu PDF