Dynamic optical breast imaging: A novel technique to detect and characterize tumor vessels
| Autor: | Laure Fournier, Daniel Vanel, Anwar R. Padhani, Corinne Balleyguier, Robert Sigal, Wolfgang Gatzemeier, Clarisse Dromain, A. Athanasiou, Alberto Costa, I.V. Masuykov, Ken Galetti |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Breast imaging Dynamic imaging Population Breast Neoplasms Sensitivity and Specificity Young Adult Breast cancer Image Interpretation Computer-Assisted Photography Medical imaging medicine Humans Mammography Radiology Nuclear Medicine and imaging education Lighting Aged Aged 80 and over Dynamic Optical Breast Imaging education.field_of_study Neovascularization Pathologic medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Middle Aged Image Enhancement medicine.disease Female Breast disease Radiology business Algorithms |
| Zdroj: | European Journal of Radiology. 69:43-49 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2008.07.038 |
| Popis: | Purpose To prospectively determine the diagnostic accuracy of optical absorption imaging in patients with Breast Imaging Reporting and Data System (BI-RADS) 3–5 breast lesions. Materials and methods Forty-six patients with BI-RADS classification 3 (11%), 4 (44%) or 5 (44%) lesions, underwent a novel optical imaging examination using red light to illuminate the breast. Pressure was applied on the breast, and time-dependent curves of light absorption were recorded. Curves that consistently increased or decreased over time were classified as suspicious for malignancy. All patients underwent a core or surgical biopsy. Results Optical mammography showed a statistical difference in numbers of suspect pixels between benign ( N =12) and malignant ( N =35) lesions (respectively 1325 vs. 3170, P =0.002). In this population, optical imaging had a sensitivity of 74%, specificity of 92%, and diagnostic accuracy of 79%. The optical signal did not vary according to any other parameter including breast size or density, age, hormonal status or histological type of lesions. Conclusion Optical imaging is a low-cost, non-invasive technique, yielding physiological information dependent on breast blood volume and oxygenation. It appears to have a good potential for discriminating benign from malignant lesions. Further studies are warranted to define its potential role in breast cancer imaging. |
| Databáze: | OpenAIRE |
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