Global Cerebral Blood Flow and Metabolism during Acute Hyperketonemia in the Awake and Anesthetized Rat
| Autor: | Olaf B. Paulson, Steen G. Hasselbalch, Peter Lund Madsen, Rasmus Linde, Simon Topp |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Magnetic Resonance Spectroscopy Intracellular pH Oxygene chemistry.chemical_element Ketone Bodies Biology Sensitivity and Specificity Oxygen Rats Sprague-Dawley Central nervous system disease Internal medicine medicine Animals Anesthesia Wakefulness Infusions Intravenous computer.programming_language 3-Hydroxybutyric Acid Brain Phosphorus Isotopes Metabolism Blood flow Hydrogen-Ion Concentration medicine.disease Rats Disease Models Animal Sodium Bicarbonate Endocrinology nervous system Neurology Cerebral blood flow chemistry Cerebrovascular Circulation Acute Disease Ketone bodies Neurology (clinical) Cardiology and Cardiovascular Medicine computer |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 26:170-180 |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1038/sj.jcbfm.9600177 |
| Popis: | In the human setting, it has been shown that acute increase in the concentration of ketone bodies by infusion of β-hydroxybutyrate increased the cerebral blood flow (CBF) without affecting the overall cerebral metabolic activity. The mechanism by which this effect of ketone bodies was mediated is not known. Alterations in several parameters may possibly explain the increase in CBF and the resetting of the relation between CBF and cerebral metabolism. To study this phenomenon further, we measured global CBF and global cerebral metabolism with the Kety–Schmidt technique in the wakeful rat before and during infusion of ketone bodies. During acute hyperketonemia (average concentration of β-hydroxybutyrate: 6 mmol/L), global CBF increased 65% from 108 to 178 mL/***100 g min and the cerebral metabolic rates for both oxygen and glucose remained constant. This resetting of the relation between CBF and cerebral metabolism could not be explained by alterations in blood pH or arterial CO2 tension. By measuring cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy, it could further be concluded that the brain pH was unchanged during acute hyperketonemia. These observations indicate that the mechanism responsible for the increase in CBF is rather a direct effect on the cerebral endothelium than via some metabolic interactions. |
| Databáze: | OpenAIRE |
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