Complications after Bilateral Adrenalectomy for Phaeochromocytoma in Multiple Endocrine Neoplasia Type 2 - a Plea to Conserve Adrenal Function
| Autor: | J. S. de Graaf, R. P. Zwierstra, Robin P. F. Dullaart |
|---|---|
| Přispěvatelé: | Lifestyle Medicine (LM) |
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male PHEOCHROMOCYTOMA medicine.medical_specialty Time Factors complications medicine.medical_treatment phaeochromocytoma Splenectomy Adrenal Gland Neoplasms Multiple Endocrine Neoplasia Type 2a Multiple endocrine neoplasia type 2 DISEASE Pheochromocytoma Postoperative Complications Addison Disease MANAGEMENT Humans Medicine multiple endocrine neoplasia Multiple endocrine neoplasia business.industry Adrenalectomy adrenalectomy Retrospective cohort study Perioperative medicine.disease Surgery Addisonian crisis EXPERIENCE Female business Complication Follow-Up Studies |
| Zdroj: | European Journal of Surgery, 165(9), 843-846 |
| ISSN: | 1102-4151 |
| DOI: | 10.1080/11024159950189320 |
| Popis: | Objective: To evaluate the complications of the adrenocortical supplementation that is needed after bilateral adrenalectomy for phaeochromocytoma in patients with multiple endocrine neoplasia (MEN) type 2 syndrome. Design: Retrospective study. Setting: University hospital, The Netherlands. Materials: 28 patients with MEN 2 who underwent total adrenalectomy for phaeochromocytoma between 1972 and 1996. Main outcome measures: Perioperative morbidity and mortality, histopathological findings, complications of adrenocortical supplementation therapy. Results: 22 patients had bilateral phaeochromocytomas on histopathological examination (79%) and 6 patients had initially unilateral phaeochromocytomas There was no operative mortality or substantial morbidity except for one splenic injury that necessitated splenectomy. During a mean follow-up period of 14 years (range 1-26) nine patients (32%) had a total of 19 Addisonian crises that necessitated admission to hospital. One patient died of an unrecognised Addisonian crisis. Conclusion: Complications of adrenocortical supplementation therapy are considerable, but they can be reduced when unilateral adrenalectomy is done for a unilateral phaeochromoytoma in patients with MEN 2 syndrome, provided that they are carefully followed up. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|