Effects of neuromuscular blocking agents on uterine contractions in vitro
| Autor: | Walter G. Moster, Charles E. Reier |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Decamethonium Compounds
Tubocurarine Succinylcholine Pharmacology In Vitro Techniques Oxytocin Tubocurarine chloride medicine Spontaneous contraction Humans SUCCINYLCHOLINE CHLORIDE Gallamine Triethiodide business.industry Gallamine triethiodide Uterus Obstetrics and Gynecology Neuromuscular Blocking Agents In vitro Anesthesia Neuromuscular Depolarizing Agents Female Halothane business medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | American journal of obstetrics and gynecology. 108(4) |
| ISSN: | 0002-9378 |
| Popis: | The direct effect of competitive and noncompetitive neuromuscular blocking agents on uterine contractions was observed in vitro. Exposure of human gravid myometrial strips to succinylcholine chloride, decamethonium iodide, gallamine triethiodide, and d -tubocurarine chloride in concentrations equivalent to one hundred times the paralyzing dose failed to significantly affect spontaneous or oxytocin stimulated contractions. By contrast, halothane produced complete inhibition of spontaneous contractions, which was completely reversed by discontinuance of the agent. These results support the contention that the role of neuromuscular blocking agents in the management of obstetric emergencies requiring uterine relaxation is limited to relaxation of the abdominal and perineal musculature, and to facilitation of anesthetic management. |
| Databáze: | OpenAIRE |
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