The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) as a characteristic component of bacterial endotoxin -- a review of its biosynthesis, function, and placement in the lipopolysaccharide core
| Autor: | Jolanta Lodowska, Ludmiła Węglarz, Daniel Wolny |
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| Rok vydání: | 2013 |
| Předmět: |
Lipopolysaccharide
Bacteria Stereochemistry 3-Deoxy-D-manno-oct-2-ulosonic acid Immunology Sugar Acids General Medicine Carbohydrate Applied Microbiology and Biotechnology Microbiology Lipid A Endotoxins chemistry.chemical_compound Biosynthesis chemistry Biochemistry Glucosamine Genetics lipids (amino acids peptides and proteins) Sugar Molecular Biology Function (biology) |
| Zdroj: | Canadian journal of microbiology. 59(10) |
| ISSN: | 1480-3275 |
| Popis: | The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) is a characteristic component of bacterial lipopolysaccharide (LPS, endotoxin). It connects the carbohydrate part of LPS with C6 of glucosamine or 2,3-diaminoglucose of lipid A by acid-labile α-ketosidic linkage. The number of Kdo units present in LPS, the way they are connected, and the occurrence of other substituents (P, PEtn, PPEtn, Gal, or β-l-Ara4N) account for structural diversity of the inner core region of endotoxin. In a majority of cases, Kdo is crucial to the viability and growth of bacterial cells. In this paper, the biosynthesis of Kdo and the mechanism of its incorporation into the LPS structure, as well as the location of this unique component in the endotoxin core structures, have been described. |
| Databáze: | OpenAIRE |
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