Significance and quantitative analysis of von Willebrand factor in human platelets
| Autor: | Th. Eller, P. Brauer, J. Mayer, J. Albert, F. Keller |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Blood Platelets
Male Immunodiffusion congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Blood Donors Enzyme-Linked Immunosorbent Assay Hemorrhage Reference range Genetic transmission Von Willebrand factor hemic and lymphatic diseases Internal medicine von Willebrand Factor Coagulopathy medicine Von Willebrand disease Humans Platelet Genes Dominant biology business.industry Hematology medicine.disease Pedigree Endocrinology Coagulation cardiovascular system biology.protein Female business Quantitative analysis (chemistry) circulatory and respiratory physiology |
| Zdroj: | Thrombosis Research. 65:631-640 |
| ISSN: | 0049-3848 |
| Popis: | The von Willebrand factor (vWF) is found in plasma and in platelets. The concentration and multimeric composition of the vWF in platelets of 160 patients with bleeding tendency were examined sincs very little is known about the platelet vWF. For quantitative analysis of the platelet vWF, a modified ELISA was established. A reference range from 70% – 130% of platelet vWF concentration consisidered normal was established by examining 80 healthy blood donors. 16.9% of the 160 patients showed a decreased vWF concentration in platelets only, while all the other coagulation parameters were normal. 3 of our patients belong to the same family and suggesting an autosomal dominant genetic transmission for the von Willebrand disease type 1–3. The data also suggeste, that a quantitative and qualitative analysis of the vWF in plasma and platelets is required for an exact diagnosis of the von Willebrand disease. |
| Databáze: | OpenAIRE |
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