Carbapenem-Resistant Klebsiella pneumoniae Associated with COVID-19
| Autor: | Irina Magdalena Dumitru, Dalia Sorina Carp, Nicoleta Dorina Vlad, Anca Dumitrescu, Rodica Lesanu, Raluca Elena Slujitoru, Aura Gherghina, Licdan Curtali, Sorin Rugină, Carmen Ilie-Serban, Corina Mitroi-Maxim, Aurelia Hangan, Mirela Dumitrascu, Roxana Carmen Cernat, Romelia Mitan |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Klebsiella pneumoniae medicine.drug_class Avibactam 030106 microbiology Antibiotics Ceftazidime Case Report RM1-950 030501 epidemiology Biochemistry Microbiology law.invention carbapenemase 03 medical and health sciences chemistry.chemical_compound law Internal medicine Intensive care medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics biology business.industry COVID-19 Antimicrobial biology.organism_classification Intensive care unit KPC Infectious Diseases chemistry carbapenem-resistant Klebsiella pneumoniae Therapeutics. Pharmacology 0305 other medical science business medicine.drug |
| Zdroj: | Antibiotics Antibiotics, Vol 10, Iss 561, p 561 (2021) |
| ISSN: | 2079-6382 |
| Popis: | Infections with carbapenem-resistant Enterobacteriaceae are emerging as an important challenge in healthcare settings. Currently, carbapenem-resistant Klebsiella pneumoniae (CRKP) are the species of CRE most commonly encountered in hospitals. CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been associated with high rates of morbidity and mortality, particularly among persons with prolonged hospitalization exposed to invasive devices. We report nine patients hospitalized in an intensive care unit (ICU) with severe coronavirus disease 2019 (COVID-19) who developed invasive infections due to carbapenemase-producing Klebsiella pneumoniae (CP-Kp), KPC and OXA-48, strains that have not been previously identified in our hospital. Despite ceftazidime/avibactam therapy, five patients died. Coinfections can contribute to a poor prognosis for patients with COVID-19, especially for high-risk populations such as elderly patients. Therefore, it is crucial to establish a rigorous program of antibiotic administration in intensive care units. |
| Databáze: | OpenAIRE |
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