Marrow damage and hematopoietic recovery following allogeneic bone marrow transplantation for acute leukemias: Effect of radiation dose and conditioning regimen

Autor: Jennifer Holter Chakrabarty, Kathryn E. Dusenbery, Leslie C. Sharkey, Shernan G. Holtan, Priya Premakanthan, Guy Storme, Susanta K. Hui, Michael R. Verneris, Daohong Zhou, Renzo Corvò, Stefano Vagge, Marc Mahe, Mukta Arora, Christopher Wilke, Sophia Yohe, Daniel J. Weisdorf, Todd E. DeFor
Přispěvatelé: Clinical sciences, Translational Radiation Oncology and Physics, Vriendenkring VUB, Radiation Therapy
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Male
Pathology
Postoperative Complications/pathology
Transplantation Conditioning
Marrow cellularity
Umbilical cord
0302 clinical medicine
Postoperative Complications
Bone Marrow
hemic and lymphatic diseases
Longitudinal Studies
Hematopoietic Stem Cells/pathology
Transplantation Conditioning/methods
Leukemia
Hematology
Total body irradiation
Middle Aged
Peripheral
Haematopoiesis
medicine.anatomical_structure
030220 oncology & carcinogenesis
Acute Disease
Female
Whole-Body Irradiation
Homologous
medicine.medical_specialty
Bone marrow transplantation
Radiation Dosage
Article
03 medical and health sciences
Leukemia/therapy
Internal medicine
medicine
Transplantation
Homologous

Humans
Radiology
Nuclear Medicine and imaging

Hematopoietic Stem Cells
Bone Marrow Transplantation
Transplantation
business.industry
medicine.disease
Bone Marrow/pathology
030104 developmental biology
Bone marrow
business
ISSN: 2003-2013
Popis: BACKGROUND AND PURPOSE: Total body irradiation (TBI) is a common component of hematopoietic cell transplantation (HCT) conditioning regimens. Preclinical studies suggest prolonged bone marrow (BM) injury after TBI could contribute to impaired engraftment and poor hematopoietic function. MATERIALS AND METHODS: We studied the longitudinal changes in the marrow environment in patients receiving allogeneic HCT with myeloablative (MA, n=42) and reduced intensity (RIC, n=56) doses of TBI from 2003-2013, including BM cellularity, histologic features of injury and repair, hematologic and immunologic recovery. RESULTS: Following MA conditioning, a 30% decrease in the marrow cellularity persisted at 1 year post-transplant (p=0.03). RIC HCT marrow cellularity transiently decreased but returned to baseline by 6 months even though the RIC group received mostly umbilical cord blood (UCB) grafts (82%, vs. 17% in the MA cohort, p
Databáze: OpenAIRE