Marrow damage and hematopoietic recovery following allogeneic bone marrow transplantation for acute leukemias: Effect of radiation dose and conditioning regimen
Autor: | Jennifer Holter Chakrabarty, Kathryn E. Dusenbery, Leslie C. Sharkey, Shernan G. Holtan, Priya Premakanthan, Guy Storme, Susanta K. Hui, Michael R. Verneris, Daohong Zhou, Renzo Corvò, Stefano Vagge, Marc Mahe, Mukta Arora, Christopher Wilke, Sophia Yohe, Daniel J. Weisdorf, Todd E. DeFor |
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Přispěvatelé: | Clinical sciences, Translational Radiation Oncology and Physics, Vriendenkring VUB, Radiation Therapy |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Oncology Male Pathology Postoperative Complications/pathology Transplantation Conditioning Marrow cellularity Umbilical cord 0302 clinical medicine Postoperative Complications Bone Marrow hemic and lymphatic diseases Longitudinal Studies Hematopoietic Stem Cells/pathology Transplantation Conditioning/methods Leukemia Hematology Total body irradiation Middle Aged Peripheral Haematopoiesis medicine.anatomical_structure 030220 oncology & carcinogenesis Acute Disease Female Whole-Body Irradiation Homologous medicine.medical_specialty Bone marrow transplantation Radiation Dosage Article 03 medical and health sciences Leukemia/therapy Internal medicine medicine Transplantation Homologous Humans Radiology Nuclear Medicine and imaging Hematopoietic Stem Cells Bone Marrow Transplantation Transplantation business.industry medicine.disease Bone Marrow/pathology 030104 developmental biology Bone marrow business |
ISSN: | 2003-2013 |
Popis: | BACKGROUND AND PURPOSE: Total body irradiation (TBI) is a common component of hematopoietic cell transplantation (HCT) conditioning regimens. Preclinical studies suggest prolonged bone marrow (BM) injury after TBI could contribute to impaired engraftment and poor hematopoietic function. MATERIALS AND METHODS: We studied the longitudinal changes in the marrow environment in patients receiving allogeneic HCT with myeloablative (MA, n=42) and reduced intensity (RIC, n=56) doses of TBI from 2003-2013, including BM cellularity, histologic features of injury and repair, hematologic and immunologic recovery. RESULTS: Following MA conditioning, a 30% decrease in the marrow cellularity persisted at 1 year post-transplant (p=0.03). RIC HCT marrow cellularity transiently decreased but returned to baseline by 6 months even though the RIC group received mostly umbilical cord blood (UCB) grafts (82%, vs. 17% in the MA cohort, p |
Databáze: | OpenAIRE |
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