Effect of occlusal splint on interleukin 6, malondialdehyde and 8-hydroxydeoxyguanosine levels in the synovial fluid of patients with temporomandibular disorders
| Autor: | A.A. Öz, Burcu Baş, Nükhet Kütük, Ö. Kaya, Enes Atmaca, Abdurrahman Aksoy, Dilara Kazan, Esmeray Mutlu Yilmaz |
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| Přispěvatelé: | KÜTÜK, NÜKHET, Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
medicine.medical_treatment Dentistry Temporomandibular disorders Occlusal Splints 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 8-hydroxydeoxyguanosine stomatognathic system Malondialdehyde Synovial Fluid medicine Humans Synovial fluid oxidative stress Interleukin 6 biology Interleukin-6 business.industry Deoxyguanosine Arthrocentesis 030206 dentistry Temporomandibular Joint Disorders Temporomandibular joint stomatognathic diseases Treatment Outcome medicine.anatomical_structure Otorhinolaryngology chemistry 8-Hydroxy-2'-Deoxyguanosine inflammation 030220 oncology & carcinogenesis biology.protein Surgery Oral Surgery Splint (medicine) business |
| Popis: | Atmaca, Enes/0000-0002-8978-3755; Aksoy, Abdurrahman/0000-0001-9486-312X; Kutuk, Nukhet/0000-0001-6563-1899; YILMAZ, EREN/0000-0003-0298-734X WOS: 000501401300009 PubMed: 31109746 The actual role of splint therapy in preventing excessive loading of the temporomandibular joint (TMJ) is still debated. Lower intra-articular pressure levels have been measured in patients wearing occlusal splints, which may also reduce oxidative stress in the articular spaces. The aim of this study was to determine whether splint therapy reduces oxidative stress and inflammation in TMJ internal derangement patients by measuring interleukin 6 (IL-6), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) levels in the synovial fluid (SF). Twenty-four patients with a temporomandibular disorder (TMD) were included in the study. TMJ SF samples were obtained prior to arthrocentesis. Twelve patients used a 2-mm hard acrylic, maxillary stabilization-type splint for 3 months after arthrocentesis. Twelve patients had no treatment after the SF aspiration. Second SF samples were obtained from all patients at 3 months post arthrocentesis. IL-6, MDA, and 8-OHdG levels in the samples were evaluated. All patients showed a significant symptomatic improvement after treatment (P < 0.005). No statistical correlation was found between the two groups concerning pre-treatment and 3-month SF levels of MDA, 8-OHdG, and IL-6. Although splint therapy was found to be successful in eliminating clinical symptoms of TMD, the results showed no beneficial effect on inflammation and oxidative stress markers in the synovial fluid. OMU Scientific Research Foundation [PYO.DIS.1901.15.005] This study was supported by OMU Scientific Research Foundation with the project number of PYO.DIS.1901.15.005. |
| Databáze: | OpenAIRE |
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