Selective Inhibition of Liver Cancer Cells Using Venom Peptide

Autor: Jeannette Huaman, Michael Lyudmer, Carolina Santamaria, Prachi Anand, Marouf Hossain, Kelly Huang, Olorunseun O. Ogunwobi, Petr Filipenko, Mandë Holford
Jazyk: angličtina
Rok vydání: 2019
Předmět:
trp channel
Carcinoma
Hepatocellular
medicine.medical_treatment
Down-Regulation
Mollusk Venoms
Pharmaceutical Science
Apoptosis
Peptide
Article
Cell Line
Targeted therapy
liver cancer
Mice
03 medical and health sciences
Transient receptor potential channel
0302 clinical medicine
Cell Line
Tumor
Drug Discovery
venom peptide
medicine
Animals
Humans
terebrid snail
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
cox-2
lcsh:QH301-705.5
Ion channel
030304 developmental biology
chemistry.chemical_classification
Mice
Inbred BALB C
0303 health sciences
Liver Neoplasms
Cancer
Hep G2 Cells
medicine.disease
3. Good health
Gene Expression Regulation
Neoplastic
chemistry
Mechanism of action
lcsh:Biology (General)
Cyclooxygenase 2
030220 oncology & carcinogenesis
Cancer research
Female
medicine.symptom
Peptides
Liver cancer
Zdroj: Marine Drugs, Vol 17, Iss 10, p 587 (2019)
Marine Drugs
Volume 17
Issue 10
ISSN: 1660-3397
Popis: Increasingly cancer is being viewed as a channelopathy because the passage of ions via ion channels and transporters mediate the regulation of tumor cell survival, death, and motility. As a result, a potential targeted therapy for cancer is to use venom peptides that are selective for ion channels and transporters overexpressed in tumor cells. Here we describe the selectivity and mechanism of action of terebrid snail venom peptide, Tv1, for treating the most common type of liver cancer, hepatocellular carcinoma (HCC). Tv1 inhibited the proliferation of murine HCC cells and significantly reduced tumor size in Tv1-treated syngeneic tumor-bearing mice. Tv1&rsquo
s mechanism of action involves binding to overexpressed transient receptor potential (TRP) channels leading to calcium dependent apoptosis resulting from down-regulation of cyclooxygenase-2 (COX-2). Our findings demonstrate the importance of modulating ion channels and the unique potential of venom peptides as tumor specific ligands in the quest for targeted cancer therapies.
Databáze: OpenAIRE
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